2-(苄氧基)-4-氟苯甲醛合成路线 （共 8 条）
反应条件
magnesium in tetrahydrofuran T=65°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; SHIONOGI and CO. LTD; KAWASUJI, Takashi
Patent: WO2007/19098 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide 2.5 h; Heating;
参考文献
Blair; Kurrasch-Orbaugh; Marona-Lewicka; Gumbay; Watts; Barker; Nichols
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4701 - 4710
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/5909 A1, 2006 ;
Location in patent: Page/Page column 38 ;
WO 2006/005909 A1
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-76°C; Swern Oxidation; 1.5 h; 2: With triethylamine in dichloromethane T=20°C;
参考文献
ACADIA PHARMACEUTICALS, INC.; SCHLIENGER, Nathalie; THYGESEN, Mikkel; ULDAM, Henriette, Kold; SCHMELZER, Kara; TABATABAEI, Ali
Patent: WO2010/111353 A1, 2010 ;
Location in patent: Page/Page column 64-65 ;
WO 2010/111353 A1
参考文献
Tsuji, Kiyoshi; Terasaka, Tadashi; Nakamura, Katsuya
Patent: US2004/97571 A1, 2004 ;
反应条件
1: Mg / methanol; toluene / Heating 2: 91 percent / K2CO3 / dimethylformamide / 2.5 h / Heating View Scheme
参考文献
Blair; Kurrasch-Orbaugh; Marona-Lewicka; Gumbay; Watts; Barker; Nichols
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4701 - 4710
反应条件
sodium tetrahydroborate in ethanol T=0°C; 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; SHIONOGI and CO. LTD; KAWASUJI, Takashi
Patent: WO2007/19098 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
1: NaOMe / methanol / -20 - -8 °C 2: xylene / Heating 3: 97 percent / aq. NaOH / Heating 4: 81 percent / Cu; N-methylpyrrolidinone / 6 h / 240 - 250 °C View Scheme
参考文献
Blair; Kurrasch-Orbaugh; Marona-Lewicka; Gumbay; Watts; Barker; Nichols
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4701 - 4710
