2-甲基-2-丙基4-戊烯-1-基氨基甲酸酯合成路线 （共 54 条）
反应条件
1: PPh3; diisopropylazadicarboxylate / tetrahydrofuran / 20 °C
2: NH2NH2*H2O / pentane / 0.25 h
3: 64 percent / Et3N / CH2Cl2
View Scheme
参考文献
Michael, Forrest E.; Cochran, Brian M.
Journal of the American Chemical Society, 2006 , vol. 128, # 13 p. 4246 - 4247
反应条件
1: NH2NH2*H2O / pentane / 0.25 h
2: 64 percent / Et3N / CH2Cl2
View Scheme
参考文献
Michael, Forrest E.; Cochran, Brian M.
Journal of the American Chemical Society, 2006 , vol. 128, # 13 p. 4246 - 4247
反应条件
1: para-iodoanisole With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1: 3-iodo-α,α,α-trifluorotoluene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1: 4-hydroxyiodobenzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1: LiAlH4 / tetrahydrofuran / 0 - 20 °C
2: 67 percent / diethyl ether / 4 h
View Scheme
参考文献
Bertrand, Myra Beaudoin; Wolfe, John P.
Tetrahedron, 2005 , vol. 61, # 26 p. 6447 - 6459
反应条件
1: 1-bromo-4-methoxy-benzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1: iodobenzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1: 2-iodophenol With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
反应条件
1: 3-methoxy-iodobenzene With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); iodine; zinc in N,N-dimethyl-formamide
T=0°C; Negishi coupling reaction; Inert atmosphere;
2: (S)-N-Boc-2-(iodomethyl)pyrrolidine in N,N-dimethyl-formamide
T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Massah, Ahmad Reza; Ross, Andrew J.; Jackson, Richard F. W.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8275 - 8278
