2-[4-(三氟甲基)苯基]吡啶合成路线 （共 21 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in tetrahydrofuran; water
T=70°C; 24 h;
参考文献
Xu, Qiu-Lei; Wang, Cheng-Cheng; Li, Tian-Yi; Teng, Ming-Yu; Zhang, Song; Jing, Yi-Ming; Yang, Xu; Li, Wei-Nan; Lin, Chen; Zheng, You-Xuan; Zuo, Jing-Lin; You, Xiao-Zeng
Inorganic Chemistry, 2013 , vol. 52, # 9 p. 4916 - 4925
反应条件
manganese; NiBr2(2,2'-bipyridine); trifluoroacetic acid in N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
Gosmini, Corinne; Bassene-Ernst, Carine; Durandetti, Muriel
Tetrahedron, 2009 , vol. 65, # 31 p. 6141 - 6146
反应条件
manganese; NiBr2(2,2'-bipyridine); trifluoroacetic acid in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Gosmini, Corinne; Bassene-Ernst, Carine; Durandetti, Muriel
Tetrahedron, 2009 , vol. 65, # 31 p. 6141 - 6146
反应条件
C42H64O4P2Pd in tetrahydrofuran
T=60°C; Kumada-Corriu coupling reaction; 20 h; Inert atmosphere; chemoselective reaction;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.; Kapdi, Anant R.; Schulzke, Carola
Chemistry - A European Journal, 2010 , vol. 16, # 11 p. 3300 - 3303
反应条件
C42H64O4P2Pd in tetrahydrofuran
T=60°C; Kumada-Corriu coupling reaction; 20 h; Inert atmosphere; chemoselective reaction;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.; Kapdi, Anant R.; Schulzke, Carola
Chemistry - A European Journal, 2010 , vol. 16, # 11 p. 3300 - 3303
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran
T=65°C; Negishi cross-coupling; 2.5 h; Inert atmosphere;
参考文献
Luzung, Michael R.; Patel, Jigar S.; Yin, Jingjun
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8330 - 8332
反应条件
Ni(PCy3)2Cl2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=25 - 100°C; 20 h; Schlenk techniqueInert atmosphere;
参考文献
Zhu, Feng; Wang, Zhong-Xia
Journal of Organic Chemistry, 2014 , vol. 79, # 10 p. 4285 - 4292
反应条件
water; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
18 h; Heating;
参考文献
Lohse, Olivier; Thevenin, Philippe; Waldvogel, Erwin
Synlett, 1999 , # 1 p. 45 - 48
反应条件
C32H26ClN2NiP in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=85°C; 12 h; Inert atmosphere;
参考文献
Zhang, Xue-Qi; Wang, Zhong-Xia
Journal of Organic Chemistry, 2012 , vol. 77, # 7 p. 3658 - 3663
反应条件
tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; silver(l) oxide in tetrahydrofuran; N,N-dimethyl-formamide
T=90°C; 18 h;
参考文献
Napier, Spencer; Marcuccio, Sebastian M.; Tye, Heather; Whittaker, Mark
Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6314 - 6315
