2-[4-(三氟甲基)苯基]吡啶合成路线 （共 21 条）
反应条件
1: 1-chloro-4-(trifluoromethyl)benzene With 3-chloroprop-1-ene; trifluoroacetic acid; zinc; Co(2,2'-bipyridine)Br2 in pyridine; N-dodecane; acetonitrile
T=50°C;
2: 2-bromo-pyridine With bis-triphenylphosphine-palladium(II) chloride in pyridine; N-dodecane; acetonitrile
T=50°C; Negishi coupling;
参考文献
Kazmierski, Igor; Gosmini, Corinne; Paris, Jean-Marc; Perichon, Jacques
Synlett, 2006 , # 6 p. 881 - 884
反应条件
C27H22Cl2N3NiP in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
12 h; Inert atmosphereSchlenk techniqueHeating;
参考文献
Zhang, Qiang; Zhang, Xue-Qi; Wang, Zhong-Xia
Dalton Transactions, 2012 , vol. 41, # 34 p. 10453 - 10464,12
反应条件
copper acetylacetonate; potassium tert-butylate; oxygen in toluene
T=110°C; 2 h;
参考文献
Shen, Yan; Chen, Jiuxi; Liu, Miaochang; Ding, Jinchang; Gao, Wenxia; Huang, Xiaobo; Wu, Huayue
Chemical Communications, 2014 , vol. 50, # 33 p. 4292 - 4295
反应条件
copper(I) oxide; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; palladium dichloride in N,N-dimethyl acetamide
T=150°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Li, Xinjian; Zou, Dapeng; Leng, Faqiang; Sun, Chunxia; Li, Jingya; Wu, Yangjie; Wu, Yusheng
Chemical Communications, 2013 , vol. 49, # 3 p. 312 - 314
反应条件
1: 1-trifluoromethyl-4-bromobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; Negishi coupling reaction; 0.5 h;
2: pyridin-2-ylzinc bromide With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=65°C; Negishi coupling reaction; 1 h;
参考文献
Coleridge, Brian M.; Bello, Charles S.; Ellenberger, David H.; Leitner, Andreas
Tetrahedron Letters, 2010 , vol. 51, # 2 p. 357 - 359
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; water; toluene
20 h; Inert atmosphereSchlenk techniqueReflux;
参考文献
Zhou, Bingwei; Chen, Hui; Wang, Congyang
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1264 - 1267
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere; |Schlenk technique
1.2: -78 - 20 °C / |Inert atmosphere; |Schlenk technique
2.1: hydrogenchloride / water / 20 °C / |Inert atmosphere; |Schlenk technique
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene; ethanol / 20 h / |Inert atmosphere; |Schlenk technique; |Reflux
View Scheme
参考文献
Zhou, Bingwei; Chen, Hui; Wang, Congyang
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1264 - 1267
反应条件
1: hydrogenchloride / water / 20 °C / |Inert atmosphere; |Schlenk technique
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene; ethanol / 20 h / |Inert atmosphere; |Schlenk technique; |Reflux
View Scheme
参考文献
Zhou, Bingwei; Chen, Hui; Wang, Congyang
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1264 - 1267
反应条件
Br(1-)*C18H28N3(1+); sodium t-butanolate
T=110°C; 48 h; Inert atmosphere;
参考文献
Chen, Wen-Ching; Hsu, Yu-Chen; Shih, Wei-Chun; Lee, Ching-Yu; Chuang, Wen-Han; Tsai, Yi-Fang; Chen, Peter Ping-Yu; Ong, Tiow-Gan
Chemical Communications, 2012 , vol. 48, # 53 p. 6702 - 6704
反应条件
[Ni(2,2'-bipyridine)3(2+)][BF4(1-)]2; zinc dibromide
1.) DMF, electrolysis, 2.) DMF, rt; Yield given. Multistep reaction;
参考文献
Gosmini, Corinne; Lasry, Sarah; Nedelec, Jean-Yves; Perichon, Jacques
Tetrahedron, 1998 , vol. 54, # 7 p. 1289 - 1298
