2-溴-3-羟基-4-硝基-苯甲腈合成路线 （共 4 条）
反应条件
in hexane; dichloromethane; ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US6204294 B1, 2001 ;
US 6204294 B1
反应条件
hydrogene tribromide; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in dichloromethane T=25°C; 72 h;
参考文献
Widdowson, Katherine L.; Elliott, John D.; Veber, Daniel F.; Nie, Hong; Rutledge, Melvin C.; McCleland, Brent W.; Xiang, Jia-Ning; Jurewicz, Anthony J.; Hertzberg, Robert P.; Foley, James J.; Griswold, Don E.; Martin, Lenox; Lee, Judithann M.; White, John R.; Sarau, Henry M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1319 - 1321
反应条件
1: 22 percent / sodium nitrate; aq. sulfuric acid; NaNO2 / CH2Cl2 / 16 h / 25 °C 2: 30 percent / hexamethylene tetramine; hydrogen tribromide / CH2Cl2 / 72 h / 25 °C View Scheme
参考文献
Widdowson, Katherine L.; Elliott, John D.; Veber, Daniel F.; Nie, Hong; Rutledge, Melvin C.; McCleland, Brent W.; Xiang, Jia-Ning; Jurewicz, Anthony J.; Hertzberg, Robert P.; Foley, James J.; Griswold, Don E.; Martin, Lenox; Lee, Judithann M.; White, John R.; Sarau, Henry M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1319 - 1321
反应条件
ethanol; tin(ll) chloride T=20°C; 16 h;
参考文献
Widdowson, Katherine L.; Elliott, John D.; Veber, Daniel F.; Nie, Hong; Rutledge, Melvin C.; McCleland, Brent W.; Xiang, Jia-Ning; Jurewicz, Anthony J.; Hertzberg, Robert P.; Foley, James J.; Griswold, Don E.; Martin, Lenox; Lee, Judithann M.; White, John R.; Sarau, Henry M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1319 - 1321
