2-氨基-4,5-二甲氧基苯甲酸乙酯合成路线 （共 19 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; 14 h;
参考文献
Ogita, Haruhisa; Isobe, Yoshiaki; Takaku, Haruo; Sekine, Rena; Goto, Yuso; Misawa, Satoru; Hayashi, Hideya
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 6 p. 1865 - 1871
反应条件
palladium monocarbide in ethanol
参考文献
Ortho Pharmaceutical Corporation
Patent: US4639518 A1, 1987 ;
反应条件
1: 63 percent / H2SO4 / 18 h / Heating 2: 98 percent / H2 / Pd/C / ethanol / 14 h / 20 °C View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 10, # 6 p. 1865 - 1871
反应条件
1: nitric acid; acetic acid / 0 - 5 °C 2: 10 palladium on activated charcoal; hydrogen View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4745 - 4749
反应条件
hydrogenchloride in water 0.75 h; Microwave irradiation;
参考文献
Jain, Kishor S.; Bariwal, Jitender B.; Phoujdar, Manisha S.; Nagras, Madhuri A.; Amrutkar, Rakesh D.; Munde, Manoj K.; Tamboli, Riyaj S.; Khedkar, Samrat A.; Khiste, Rahul H.; Vidyasagar, Nikhil C.; Dabholkar, Vinit V.; Kathiravan
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 178 - 185
反应条件
1: sodium; ethyl acetate 3: acetic acid anhydride 4: aqueous NH3 View Scheme
参考文献
Fetscher; Bogert
Journal of Organic Chemistry, 1939 , vol. 4, p. 71,80
反应条件
1: 160 - 170 °C 2: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 3: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 4: trichlorophosphate / toluene / Reflux 5: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: 165 - 170 °C 2: trichlorophosphate / toluene View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
