2-氨基-4,5-二甲氧基苯甲酸乙酯合成路线 （共 19 条）
反应条件
trichlorophosphate Vilsmeier-Haack Formylation; Cooling with iceMicrowave irradiation;
参考文献
Jain, Kishore S.; Kathiravan, Muthu K.; Bariwal, Jitender B.; Chaskar, Pratip K.; Tompe, Santosh S.; Arya, Nikhilesh
Synthetic Communications, 2013 , vol. 43, # 5 p. 719 - 727
参考文献
Byk Gulden Lomberg Chemische Fabrik Gesellschaft mit beschrankter Haftung
Patent: US3984555 A1, 1976 ;
反应条件
1: sodium; ethyl acetate View Scheme
参考文献
Fetscher; Bogert
Journal of Organic Chemistry, 1939 , vol. 4, p. 71,80
反应条件
1: 160 - 170 °C 2: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 3: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: 160 - 170 °C 2: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 3: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 4: trichlorophosphate / toluene / Reflux 5: pyridine / isopropyl alcohol / Reflux 6: water; sodium hydroxide / methanol View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: 160 - 170 °C 2: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
1: 160 - 170 °C 2: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 3: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 4: trichlorophosphate / toluene / Reflux View Scheme
参考文献
Li, Shilei; Wang, Xiao; He, Yong; Zhao, Mingxia; Chen, Yurong; Xu, Jingli; Feng, Man; Chang, Jin; Ning, Hongyu; Qi, Chuanmin
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 293 - 301
反应条件
hydrogenchloride in water
0.416667 h; Microwave irradiation;
参考文献
Jain, Kishor S.; Bariwal, Jitender B.; Phoujdar, Manisha S.; Nagras, Madhuri A.; Amrutkar, Rakesh D.; Munde, Manoj K.; Tamboli, Riyaj S.; Khedkar, Samrat A.; Khiste, Rahul H.; Vidyasagar, Nikhil C.; Dabholkar, Vinit V.; Kathiravan
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 178 - 185
反应条件
1: sodium; ethyl acetate
3: acetic acid anhydride
View Scheme
参考文献
Fetscher; Bogert
Journal of Organic Chemistry, 1939 , vol. 4, p. 71,80
