1: With hydrogenchloride; sodium hydroxide; sodium nitrite in water T=0 - 5°C; 0.5 h; 2: With potassium ethylxanthate in water T=75 - 80°C; 0.5 h; 3: With hydrogenchloride; sodium hydroxide; water; sodium hydrogensulfite more than 3 stages;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1897880 A1, 2008 ;
Location in patent: Page/Page column 20 ;