3,4,5-三甲基肉桂酸甲酯合成路线 (共 29 条)
反应条件
1.1: trimethylaluminum / dichloromethane / 4 h / 0 - 20 °C 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0.5 h / 20 °C 2.2: 24 h / 20 °C View Scheme
参考文献
Jung, Jae-Chul; Min, Dongguk; Lim, Heena; Moon, Sohyeon; Jung, Mankil; Oh, Seikwan
Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4615 - 4621
反应条件
1: 100 percent / DIBAL-H / CH2Cl2; toluene / 1.5 h / -78 °C 2: MnO2 / ethyl acetate View Scheme
参考文献
Banwell, Martin G.; Lambert, John N.; Gravatt, G. Lance
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 22 p. 2817 - 2830
反应条件
diisobutylaluminium hydride in dichloromethane; toluene T=-78°C; 1.5 h;
参考文献
Bourdron, Julien; Commeiras, Laurent; Barbier, Pascale; Bourgarel-Rey, Veronique; Pasquier, Eddy; Vanthuyne, Nicolas; Hubaud, Jean-Claude; Peyrot, Vincent; Parrain, Jean-Luc
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5540 - 5548
反应条件
1: H2 / Pd-C / methanol
2: LiAlH4 / diethyl ether
3: (i) TsCl, Py, (ii) /BRN= 471171/, NaH, THF, (iii) /BRN= 1209426/, Et3N, hexane
4: KOAc, AcOH
View Scheme
参考文献
Kato; Kido; Wu; Yoshikoshi
Bulletin of the Chemical Society of Japan, 1974 , vol. 47, # 4 p. 1516 - 1521
反应条件
bromine in chloroform
参考文献
Klemm,L.H. et al.
Tetrahedron, 1964 , vol. 20, p. 871 - 876
反应条件
1: Br2 / CHCl3
2: aq. KOH / ethanol / Heating
View Scheme
参考文献
Klemm,L.H. et al.
Tetrahedron, 1964 , vol. 20, p. 871 - 876
反应条件
(i) Br2, CHCl3, (ii) NaHCO3, acetone, (iii) NaNH2, liq. NH3; Multistep reaction;
参考文献
Kato; Kido; Wu; Yoshikoshi
Bulletin of the Chemical Society of Japan, 1974 , vol. 47, # 4 p. 1516 - 1521
反应条件
1: 100 percent / DIBAL-H / CH2Cl2; toluene / 1.5 h / -78 °C
2: 86 percent / Ni(OAc)2*4H2O; NaBH4; H2 / aq. ethanol
View Scheme
参考文献
Kato; Kido; Wu; Yoshikoshi
Bulletin of the Chemical Society of Japan, 1974 , vol. 47, # 4 p. 1516 - 1521
反应条件
ammonium formate; silica gel; palladium dichloride in formic acid; water
0.0666667 h; microwave irradiation;
参考文献
Kumar, Vinod; Sharma, Anuj; Sinha, Arun K.
Helvetica Chimica Acta, 2006 , vol. 89, # 3 p. 483 - 495