3，4，5-三甲氧基肉桂酸合成路线 （共 41 条）
反应条件
1: sodium-amalgam; aqueous ethanol 2: thionyl chloride; chloroform / anschliessendes Behandeln mit einer wss. Loesung von Natriumhydroxid und Ammoniak 3: alkaline aqueous sodium hypobromite View Scheme
参考文献
Slotta; Heller
Chemische Berichte, 1930 , vol. 63, p. 3029,3043
反应条件
1: triethylamine / tetrahydrofuran / 0.75 h / -20 °C
2: triethylamine / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
Rao, Vidadala Ramasubba; Muthenna, Puppala; Shankaraiah, Gundeti; Akileshwari, Chandrasekhar; Babu, Kothapalli Hari; Suresh, Ganji; Babu, Katragadda Suresh; Chandra Kumar, Rotte Sateesh; Prasad, Kothakonda Rajendra; Yadav, Potharaju Ashok; Petrash, J. Mark; Reddy, Geereddy Bhanuprakash; Rao, Janaswamy Madhusudana
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 344 - 361
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane
2 h; Ambient temperature;
参考文献
Ara; Takeya; Tobinaga
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 11 p. 1977 - 1984
反应条件
1: LiAlH4 / diethyl ether / 2 h / Heating
2: LiAlH4 / pyridine / 2 h / Ambient temperature
View Scheme
参考文献
Ehret, Charles; Maupetit, Pierre
Phytochemistry (Elsevier), 1982 , vol. 21, # 12 p. 2984 - 2985
参考文献
Burja, Bojan; Kocevar, Marijan; Polanc, Slovenko
Tetrahedron, 2009 , vol. 65, # 42 p. 8690 - 8696
反应条件
bromine
1.) ref.; 2.) CHCl3; Yield given. Multistep reaction;
参考文献
Madalengoitia; Macdonald
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6237 - 6240
反应条件
1: 1.) BF3OEt; 2.) Br2 / 1.) ref.; 2.) CHCl3
2: 28 percent / KOH / H2O; ethanol / Heating
View Scheme
参考文献
Madalengoitia; Macdonald
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6237 - 6240
反应条件
in acetonitrile
T=130°C; 0.0833333 h; Microwave irradiation;
参考文献
Chighine, Alessandra; Crosignani, Stefano; Arnal, Marie-Claire; Bradley, Mark; Linclau, Bruno
Journal of Organic Chemistry, 2009 , vol. 74, # 13 p. 4753 - 4762
反应条件
in acetonitrile
T=130°C; 0.0833333 h; Microwave irradiation;
参考文献
Chighine, Alessandra; Crosignani, Stefano; Arnal, Marie-Claire; Bradley, Mark; Linclau, Bruno
Journal of Organic Chemistry, 2009 , vol. 74, # 13 p. 4753 - 4762
反应条件
1: 81 percent / H2SO4 / Heating
2: 100 percent / DIBAL-H / CH2Cl2; toluene / 1.5 h / -78 °C
3: 86 percent / Ni(OAc)2*4H2O; NaBH4; H2 / aq. ethanol
View Scheme
参考文献
Laurent, Mathieu Y.; Stocker, Vivien; Temgoua, Valery Momo; Dujardin, Gilles; Dhal, Robert
Tetrahedron Letters, 2011 , vol. 52, # 14 p. 1608 - 1611
