米氏酸合成路线 - 魔法化学

参考文献

Griebenow, Nils; Flessner, Timo; Buchmueller, Anja; Raabe, Martin; Bischoff, Hilmar; Kolkhof, Peter
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2554 - 2558

67-56-1甲醇+

2033-24-1米氏酸+

141-75-3丁酰氯

30414-54-13-氧代己酸甲酯

参考文献

Teng, Xin; Keys, Heather; Jeevanandam, Arumugasamy; Porco Jr., John A.; Degterev, Alexei; Yuan, Junying; Cuny, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6836 - 6840

2033-24-1米氏酸+

107-46-0聚二甲基硅氧烷

18457-04-0马来酸双(三甲硅烷)酯+

67-64-1丙酮

参考文献

Rigo, B.; Fasseur, D.; Cauliez, P.; Couturier, D.
Tetrahedron Letters, 1989 , vol. 30, # 23 p. 3073 - 3076

2033-24-1米氏酸+

459-04-1对氟苯乙酰氯

221121-37-54-(4-氟苯基)-3-氧代丁酸乙酯

参考文献

DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; KAUFMAN, Michael, D.
Patent: WO2011/139891 A1, 2011 ;
Location in patent: Page/Page column 60 ;
WO 2011/139891 A1

2033-24-1米氏酸+

64-17-5乙醇+

459-04-1对氟苯乙酰氯

221121-37-54-(4-氟苯基)-3-氧代丁酸乙酯

参考文献

Terai, Takuya; Kikuchi, Kazuya; Iwasawa, Shin-Ya; Kawabe, Takao; Hirata, Yasunobu; Urano, Yasuteru; Nagano, Tetsuo
Journal of the American Chemical Society, 2006 , vol. 128, # 21 p. 6938 - 6946

2033-24-1米氏酸+

209995-38-0

1152439-73-0

参考文献

Jiangsu Hengrui Medicine Co., Ltd.
Patent: US2011/130587 A1, 2011 ;
Location in patent: Page/Page column 3-4 ;

2033-24-1米氏酸+

1176895-65-0

1152439-73-0

参考文献

MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Revu; KONDAL REDDY, Bairy; SRINIVAS, Aluru
Patent: WO2010/122578 A2, 2010 ;
Location in patent: Page/Page column 43-44 ;

2033-24-1米氏酸+

41602-56-6

122607-15-2

参考文献

Draoui, Nihed; Schicke, Olivier; Fernandes, Antony; Drozak, Xavier; Nahra, Fady; Dumont, Amelie; Douxfils, Jonathan; Hermans, Emmanuel; Dogne, Jean-Michel; Corbau, Romu; Marchand, Arnaud; Chaltin, Patrick; Sonveaux, Pierre; Feron, Olivier; Riant, Olivier
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 7107 - 7117

参考文献

Journal of Organic Chemistry, , vol. 69, # 7 p. 2595 - 2597

2033-24-1米氏酸+

111-87-5

196503-34-1

参考文献

Xia, Chun-nian; Li, Hai-bo; liu, Feng; Hu, Wei-xiao
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 24 p. 6553 - 6557