反应条件
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 2.5 h, 2.) a) 0 deg C, 0.5 h, b) RT, 2.5 h
2: 1.) n-BuLi / 1.) Et2O, TMEDA, hexane, 0 deg C, 1 h, 2.) from 0 deg C to RT
3: (COCl)2, DMF / CH2Cl2 / 1 h / 0 °C
4: CH2Cl2 / 1.5 h / 0 °C
View Scheme
参考文献
Bishop; Mathis; Gerdes; Whitney; Eaton; Mailman
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1612 - 1624