(9ci)-2-氯-1-甲基-1H-苯并咪唑-5-胺合成路线 （共 5 条）
反应条件
1: With hydrogenchloride; tin(ll) chloride in water T=100°C; 3.25 h; 2: With sodium hydroxide in water pH=9;
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2005/35526 A1, 2005 ;
Location in patent: Page/Page column 53-54 ;
WO 2005/035526 A1
反应条件
hydrogenchloride; tin T=90°C; 0.266667 h;
参考文献
Piersanti, Giovanni; Giorgi, Luca; Bartoccini, Francesca; Tarzia, Giorgio; Minetti, Patrizia; Gallo, Grazia; Giorgi, Fabrizio; Castorina, Massimo; Ghirardi, Orlando; Carminati, Paolo
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2567 - 2571
反应条件
1: With sodium hydride in N,N-dimethyl-formamide 2: With hydrogenchloride; tin(ll) chloride
参考文献
Arienzo, Rosa; Cramp, Sue; Dyke, Hazel J.; Lockey, Peter M.; Norman, Dennis; Roach, Alan G.; Smith, Phil; Wong, Melanie; Wren, Stephen P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1403 - 1407
反应条件
1: 84 percent / 5N aq. NaOH / 1 h / Ambient temperature 2: 1.) conc. HNO3, conc. H2SO4, 2.) stannous chloride dihydrate, conc. HCl / 1.) 10 deg C, 1 h, 2.) 100 deg C, 4 h View Scheme
参考文献
Galy, Jean-Pierre; Hanoun, Jean-Pierre; Pique, Valerie; Jagerovic, Nadine; Elguero, Jose
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1781 - 1787
反应条件
hydrogenchloride; sulfuric acid; nitric acid; tin(ll) chloride 1.) 10 deg C, 1 h, 2.) 100 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Galy, Jean-Pierre; Hanoun, Jean-Pierre; Pique, Valerie; Jagerovic, Nadine; Elguero, Jose
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1781 - 1787
