2,6-二氯-9-异丙基-9h-嘌呤合成路线 （共 10 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=70°C; Mitsunobu coupling; 12 h;
参考文献
Lu, Weibing; Sengupta, Sujata; Petersen, Jeffrey L.; Akhmedov, Novruz G.; Shi, Xiaodong
Journal of Organic Chemistry, 2007 , vol. 72, # 13 p. 5012 - 5015
反应条件
potassium carbonate in dimethyl sulfoxide T=15 - 20°C;
参考文献
Liang, Mary; Tarr, Tyler B.; Bravo-Altamirano, Karla; Valdomir, Guillermo; Rensch, Gabriel; Swanson, Lauren; Destefino, Nicholas R.; Mazzarisi, Cara M.; Olszewski, Rachel A.; Wilson, Gabriela Mustata; Meriney, Stephen D.; Wipf, Peter
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 12 p. 985 - 990
反应条件
potassium carbonate in dimethyl sulfoxide T=15°C;
参考文献
N'Gompaza-Diarra, Joannah; Bettayeb, Karima; Gresh, Nohad; Meijer, Laurent; Oumata, Nassima
European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 210 - 216
反应条件
potassium carbonate in dimethyl sulfoxide T=15 - 18°C; 8 h;
参考文献
Oumata, Nassima; Bettayeb, Karima; Ferandin, Yoan; Demange, Luc; Lopez-Giral, Angela; Goddard, Marie-Lorene; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Flajolet, Marc; Greengard, Paul; Meijer, Laurent; Galons, Herve
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5229 - 5242
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=20 - 25°C; Mitsunobu Displacement; 2 h; Inert atmosphere;
参考文献
Zatloukal, Marek; Jorda, Radek; Gucky, Tomas; Reznickova, Eva; Voller, Jiri; Pospisil, Tomas; Malinkova, Veronika; Adamcova, Helena; Krystof, Vladimir; Strnad, Miroslav
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 61 - 72
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; acetone
参考文献
US2003/69259 A1, ;
US 20030069259 A1
反应条件
triethylamine in butan-1-ol T=100°C; 2 h;
参考文献
Oumata, Nassima; Bettayeb, Karima; Ferandin, Yoan; Demange, Luc; Lopez-Giral, Angela; Goddard, Marie-Lorene; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Flajolet, Marc; Greengard, Paul; Meijer, Laurent; Galons, Herve
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5229 - 5242
反应条件
1: triethylamine / butan-1-ol 2: 150 °C View Scheme
参考文献
Travnicek, Zdenek; Popa, Igor; Cajan, Michal; Zboril, Radek; Krystof, Vladimir; Mikulik, Jiri
Journal of Inorganic Biochemistry, 2010 , vol. 104, # 4 p. 405 - 417
参考文献
Travnicek, Zdenek; Popa, Igor; Cajan, Michal; Zboril, Radek; Krystof, Vladimir; Mikulik, Jiri
Journal of Inorganic Biochemistry, 2010 , vol. 104, # 4 p. 405 - 417
反应条件
triethylamine in butan-1-ol
T=115°C; 3 h;
参考文献
Rypka; Vesely; Chmela; Riegrova; Cervenkova; Havliek; Lemr; Hanus; Cerny; Lukes; Michalikova
Xenobiotica, 2002 , vol. 32, # 11 p. 1017 - 1031
