2H-吡啶并[3,2-b][1,4]恶嗪-3(4H)-酮合成路线 （共 15 条）
反应条件
iron; acetic acid 2.5 h; Inert atmosphereReflux;
参考文献
Tetrahedron, , vol. 67, # 6 p. 1187 - 1192
反应条件
1: 2-amino-3-hydroxy-pyridine With sodium hydroxide; water in methanol 2: chloroacetic acid in methanol
参考文献
WO2004/14384 A2, ;
Page/Page column 256; 262 ;
WO 2004/014384 A2
反应条件
sodium hydrogencarbonate in water; butanone 1.) room temperature, 30 min, 2.) 75 deg C, 30 min;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 6, # 2 p. 133 - 142
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; [C8mim][BF4] T=20°C; 1.5 h; chemoselective reaction;
参考文献
Tetrahedron Letters, , vol. 51, # 14 p. 1852 - 1855
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium formate in N,N-dimethyl-formamide T=110°C; P=3102.97 Torr; Reagent/catalyst; Overall yield = 50 percent;
参考文献
Synthetic Communications, , vol. 43, # 24 p. 3315 - 3321
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere 1.2: 1 h / 20 °C / Inert atmosphere 2.1: iron; acetic acid / 2.5 h / Inert atmosphere; Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 6 p. 1187 - 1192
反应条件
hydrogenchloride 0.5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, # 4 p. 1081 - 1086
反应条件
1: 48 percent / K2CO3 / acetonitrile / 6 h / Heating 2: 70 percent / Sodium methoxide / methanol / 4 h / Heating 3: 82 percent / ethanol / 5 h / Heating 4: 39 percent / 8N aq. HCl / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, # 4 p. 1081 - 1086
反应条件
1: 70 percent / Sodium methoxide / methanol / 4 h / Heating 2: 82 percent / ethanol / 5 h / Heating 3: 39 percent / 8N aq. HCl / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, # 4 p. 1081 - 1086
反应条件
1: 82 percent / ethanol / 5 h / Heating 2: 39 percent / 8N aq. HCl / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, # 4 p. 1081 - 1086
