2H-吡啶并[3,2-b][1,4]恶嗪-3(4H)-酮合成路线 （共 15 条）
反应条件
(i) NaOMe, DMSO, (ii) /BRN= 506255/; Multistep reaction;
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 23, p. 2322 - 2324
反应条件
bromine in N,N-dimethyl-formamide 2 h; Ambient temperature;
参考文献
Savelon; Bizot-Espiard; Caignard; Pfeiffer; Renard; Viaud; Guillaumet
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 2 p. 133 - 142
反应条件
sulfuric acid; nitric acid T=20°C; 0.75 h;
参考文献
Shionogi and Co., Ltd.
Patent: EP2341052 A1, 2011 ;
Location in patent: Page/Page column 38-39 ;
参考文献
Clauson-Kaas,N. et al.
Acta Chemica Scandinavica (1947-1973), 1971 , vol. 25, p. 3135 - 3143
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 18 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran T=0°C;
参考文献
WO2007/53131 A2, ;
Page/Page column 133 ;
WO 2007/053131 A2
