6-甲基-2H-吡啶并[3,2-b]-1,4-噁嗪-3(4h)-酮合成路线 (共 4 条)
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 3 h;
参考文献
Nagarajan, Srinivasan R.; Khanna, Ish Kumar; Clare, Michael; Gasiecki, Alan; Rogers, Thomas; Chen, Barbara; Russell, Mark; Lu, Hwang-Fun; Yi, Yu; Huff, Renee M.; Desai, Bipinchandra N.; Devadas, Balekudru; Parikh, Mihir D.; Penning, Thomas
Patent: US2004/92538 A1, 2004 ;
Location in patent: Page 41-42 ;
反应条件
sodium hydrogencarbonate in butanone
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US2002/169200 A1, 2002 ;
反应条件
1: 2-Amino-3-hydroxy-6-methylpyridine With sodium hydride in dimethyl sulfoxide
0.25 h;
2: chloroacetic acid methyl ester in dimethyl sulfoxide
T=100°C; 3.5 h;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 72 ;
反应条件
1: 99 percent / H2 / Pd/C / ethyl acetate
2: 79 percent / aq. NaHCO3 / butan-2-one
View Scheme
参考文献
Leonard, Kristi; Pan, Wenxi; Anaclerio, Beth; Gushue, Joan M.; Guo, Zihong; DesJarlais, Renee L.; Chaikin, Marge A.; Lattanze, Jennifer; Crysler, Carl; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2679 - 2684