2-氨基-3-羟基-6-甲基吡啶合成路线 （共 10 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US2002/169200 A1, 2002 ;
参考文献
CANON KABUSHIKI KAISHA
Patent: US2008/138656 A1, 2008 ;
反应条件
1: 79 percent / aq. NaHCO3 / butan-2-one 2: 99 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Leonard, Kristi; Pan, Wenxi; Anaclerio, Beth; Gushue, Joan M.; Guo, Zihong; DesJarlais, Renee L.; Chaikin, Marge A.; Lattanze, Jennifer; Crysler, Carl; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2679 - 2684
反应条件
sodium hydroxide; sodium nitrite in HF
参考文献
Abbott Laboratories
Patent: US6133253 A1, 2000 ;
反应条件
sodium hydrogencarbonate in butanone
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US2002/169200 A1, 2002 ;
反应条件
1: 2-Amino-3-hydroxy-6-methylpyridine With sodium hydride in dimethyl sulfoxide
0.25 h;
2: chloroacetic acid methyl ester in dimethyl sulfoxide
T=100°C; 3.5 h;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 72 ;
反应条件
1.1: ethanol / 4 h / 80 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: sodium hydroxide / water / 2 h / 20 °C
3.2: 20 h / 100 °C
View Scheme
参考文献
Toray Industries, Inc.; Hayashi, Kenichi
Patent: US2014/128606 A1, 2014 ;
反应条件
1: ethanol / 4 h / 80 °C
2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
View Scheme
参考文献
Toray Industries, Inc.; Hayashi, Kenichi
Patent: US2014/128606 A1, 2014 ;
参考文献
Science et Organisation
Patent: US5084456 A1, 1992 ;
反应条件
in tetrahydrofuran
6 h; Heating;
参考文献
Flouzat, Christine; Bresson, Yvette; Mattio, Anny; Bonnet, Jacqueline; Guillaumet, Gerald
Journal of Medicinal Chemistry, 1993 , vol. 36, # 4 p. 497 - 503
