反应条件
1: 86 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 2: 86 percent / TMSOTf / CH2Cl2 / Ambient temperature 3: tetrahydrofuran / -90 °C 4: LiOH / methanol; H2O 5: 2.) i-Pr2NEt / 2.) CH2Cl2, 12 h 6: 1.) K-Selectride, 2.) i-Pr2NEt / 1.) THF, -78 deg C, 1 h, 2.) CH2Cl2, 10 h 7: 58 percent / MeI, NaHCO3 / acetonitrile; H2O / Ambient temperature 8: 1.) n-BuLi, LiBr, KOCMe3, 2.) HCl, 3.) LiOH / 1.) THF, -78 deg C, 2.) THF, room temperature, 10 h, 3.) MeOH, H2O, 10 h 9: 1.) 2,4,6-trichlorobenzoyl chloride, Et3N, DMAP, 2.) TiCl4 / 1.) THF, toluene, reflux, 6 h, 2.) CH2Cl2, 0 deg C, 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 14 p. 4552 - 4553
