4-(6-氯-2-甲基-4-嘧啶)-四氢-1(2H)-吡嗪羧酸叔丁酯合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 72 h;
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Fernandez Collado, Juan Carlos; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Mir Cepeda, Marta; Carranco Moruno, Inés
Patent: EP2489663 A1, 2012 ;
Location in patent: Paragraph 0144; 0145 ;
EP 2489663 A1
反应条件
triethylamine in ethanol; dichloromethane
反应条件
caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane
7 h; Heating / reflux;
参考文献
TARGEGEN, INC.
Patent: WO2007/56023 A2, 2007 ;
Location in patent: Page/Page column 49 ;
WO 2007/056023 A2
