5-甲氧基-2-硝基苯甲醛合成路线 （共 41 条）
反应条件
SnCl2·2H2O in methanol; ethyl acetate T=25°C; 20 h;
参考文献
Chauhan, Jay; Fletcher, Steven
Tetrahedron Letters, 2012 , vol. 53, # 37 p. 4951 - 4954
反应条件
1: 88 percent / tetrahydrofuran / 1.) -50 deg C, 4 h, 2.) r.t., 1 h
2: 88 percent / PDC / CH2Cl2 / 6 h / Heating
3: 97 percent / H2 / 5percent Pd/C / ethanol / 3 h / 760 Torr
View Scheme
参考文献
Fuerstner, Alois; Jumbam, Denis N.; Seidel, Guenter
Chemische Berichte, 1994 , vol. 127, # 6 p. 1125 - 1130
反应条件
1.1: 69 percent / Fe; HCl
2.1: t-BuONO; HBr
3.1: CuBr
4.1: TSA / benzene / 24 h / Heating
5.1: tetrahydrofuran / -78 °C
5.2: 76 percent / tetrahydrofuran
6.1: 81 percent / HCl / 12 h
View Scheme
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
反应条件
potassium borohydride
参考文献
Imperial Chemical Industries Limited
Patent: US4268510 A1, 1981 ;
反应条件
1: 88 percent / tetrahydrofuran / 1.) -50 deg C, 4 h, 2.) r.t., 1 h
2: 88 percent / PDC / CH2Cl2 / 6 h / Heating
3: 97 percent / H2 / 5percent Pd/C / ethanol / 3 h / 760 Torr
4: 77 percent / pyridine / CH2Cl2 / 1 h / Ambient temperature
5: TiCl3/C8K / 1,2-dimethoxy-ethane / 1 h / Heating
View Scheme
参考文献
Fuerstner, Alois; Jumbam, Denis N.; Seidel, Guenter
Chemische Berichte, 1994 , vol. 127, # 6 p. 1125 - 1130
反应条件
1: 69 percent / Fe; HCl
2: t-BuONO; HBr
3: CuBr
4: TSA / benzene / 24 h / Heating
View Scheme
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
反应条件
1: 88 percent / tetrahydrofuran / 1.) -50 deg C, 4 h, 2.) r.t., 1 h
2: 88 percent / PDC / CH2Cl2 / 6 h / Heating
View Scheme
参考文献
Fuerstner, Alois; Jumbam, Denis N.; Seidel, Guenter
Chemische Berichte, 1994 , vol. 127, # 6 p. 1125 - 1130
反应条件
1: 100 percent / tetrahydrofuran / 3.5 h
2: 88 percent / Jones reagent / acetone / 0.17 h / Ambient temperature
3: 98 percent / H2 / 10percent Pd(C) / ethanol / 4 h
View Scheme
参考文献
Shen, Wang; Coburn, Craig A.; Bornmann, William G.; Danishefsky, Samuel J.
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 611 - 617
反应条件
1: 92 percent / p-toluenesul;fonic acid / toluene / 6 h / Heating
2: 89 percent / sodium sulfide / ethanol; H2O / 0.5 h / Heating
View Scheme
参考文献
Caldwell, Richard D.; GUCKIAN, Kevin M.; KUMARA VEL, Gnanasambandam; LEE, Wen-Cherng; LIN, Edward Yin-Shiang; LlU, Xiaogao; MA, Bin; SCOTT, Daniel M.; SHl, Zhan; THOMAS, Jermaine; TAVERAS, Arthur G.; ZHENG, Guo Zhu
Patent: US2014/100195 A1, 2014 ;
反应条件
hydrogen; palladium on activated charcoal
T=20°C; 48 h;
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
