1.1: 7.9 g / DIBAL / tetrahydrofuran; hexane / 2 h / -78 - 20 °C 2.1: 47.3 percent / silica gel supported H2SO4 / CH2Cl2 / 20 °C 3.1: imidazole / dimethylformamide / 20 °C 4.1: AD-mixα; methanesulfonamide / H2O; 2-methyl-propan-2-ol; CH2Cl2 / 0 °C 5.1: TBAF / tetrahydrofuran / 4 h / 20 °C 6.1: triethyl orthoformate; pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 5 h / 60 °C 6.2: K2CO3 / methanol; 1,2-dimethoxy-ethane / 20 °C View Scheme

1: 85 percent / KOH / ethanol / 20 h / Heating 2: 95 percent / DMAP; EDCI / CH2Cl2 / 24 h / 20 °C 3: 92 percent / Pd(OAc)2; Et3N; Et3SiH / CH2Cl2 / 20 °C View Scheme

1: 85 percent / KOH / ethanol / 20 h / Heating 2: 95 percent / DMAP; EDCI / CH2Cl2 / 24 h / 20 °C 3: 92 percent / Pd(OAc)2; Et3N; Et3SiH / CH2Cl2 / 20 °C View Scheme

1: 85 percent / KOH / ethanol / 20 h / Heating 2: 95 percent / DMAP; EDCI / CH2Cl2 / 24 h / 20 °C 3: 92 percent / Pd(OAc)2; Et3N; Et3SiH / CH2Cl2 / 20 °C View Scheme

1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran 2: 3,4-bis(benzyloxy)benzaldehyde in tetrahydrofuran 0.166667 h; Further stages.;

in dichloromethane T=20°C; Wittig condensation; 24 h; stereoselective reaction;

potassium carbonate in ethanol 20 h; Heating;

1: 94 percent / aq. NaI, K2CO3 / aq. ethanol / 4.5 h / Heating 2: 99.5 percent / NaH / 1,2-dimethoxy-ethane / 0.33 h View Scheme

1: 94 percent / aq. NaI, K2CO3 / aq. ethanol / 4.5 h / Heating 2: 99.5 percent / NaH / 1,2-dimethoxy-ethane / 0.33 h View Scheme

sodium hydride in ethylene glycol dimethyl ether 0.5 h; Ambient temperature;