2-氨基-5-氯苯并噻唑合成路线 （共 17 条）
参考文献
PROLYSIS LTD
Patent: WO2007/107758 A1, 2007 ;
Location in patent: Page/Page column 88-89 ;
WO 2007/107758 A1
反应条件
sulfuric acid; hydrazine hydrate in ethylene glycol 4 h; Reflux;
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
potassium hydroxide in isopropyl alcohol
参考文献
Fink, Brian E.; Gavai, Ashvinikumar V.; Tokarski, John S.; Goyal, Bindu; Misra, Raj; Xiao, Hai-Yun; Kimball, S. David; Han, Wen-Ching; Norris, Derek; Spires, Thomas E.; You, Dan; Gottardis, Marco M.; Lorenzi, Matthew V.; Vite, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1532 - 1536
反应条件
1: 100 percent / KOH / propan-2-ol 2: dithiothreitol / dimethylformamide View Scheme
参考文献
Fink, Brian E.; Gavai, Ashvinikumar V.; Tokarski, John S.; Goyal, Bindu; Misra, Raj; Xiao, Hai-Yun; Kimball, S. David; Han, Wen-Ching; Norris, Derek; Spires, Thomas E.; You, Dan; Gottardis, Marco M.; Lorenzi, Matthew V.; Vite, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1532 - 1536
参考文献
Gakhar, H. K.; Gupta, Shashi Bhushan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 681 - 682
反应条件
tert.-butylnitrite; copper(ll) bromide in N,N-dimethyl-formamide T=50 - 60°C; 1.75 h;
参考文献
Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 24 p. 8206 - 8220
反应条件
1: hydrazine monohydrochloride; hydrazine hydrate / ethylene glycol / 2 h / 140 °C 2: thionyl chloride / 2 h / 50 °C View Scheme
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
