2-氨基-5-溴苯并噻唑合成路线 （共 10 条）
反应条件
1: With bromine in chloroform T=0 - 5°C; Reflux; 2: With ammonia in water
参考文献
Medicinal Chemistry Research, , vol. 21, # 7 p. 1136 - 1148
反应条件
sodium hydride in 1-methyl-pyrrolidin-2-one T=20 - 160°C; 1 h;
参考文献
WO2009/74812 A1, ;
Page/Page column 16; 17 ;
WO 2009/074812 A1
反应条件
bromine in dichloromethane T=20°C; Overall yield = 82 percent; Overall yield = 809 mg;
参考文献
WO2013/43001 A1, ;
Paragraph 838; 839 ;
反应条件
1.1: hydrogenchloride / water / 0.5 h / Reflux 1.2: 4 h / 20 °C / Reflux 2.1: bromine / chloroform / 0 - 5 °C / Reflux View Scheme
参考文献
Medicinal Chemistry Research, , vol. 21, # 7 p. 1136 - 1148
反应条件
bromine; acetic acid T=0 - 20°C; 13.75 h;
参考文献
Asian Journal of Chemistry, , vol. 23, # 9 p. 3969 - 3974
反应条件
hydrogenchloride; iron
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 268 - 272
反应条件
1: (i) aq. H2SO4, NaNO2, (ii) /BRN= 3594799/, CuSCN 2: Fe, aq. HCl View Scheme
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 268 - 272
反应条件
water; potassium hydroxide 24 h; Reflux;
参考文献
Cui, Meng-Chao; Li, Zi-Jing; Tang, Rui-Kun; Liu, Bo-Li
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 7 p. 2777 - 2784
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in dimethyl sulfoxide
T=170°C; 24 h; Inert atmosphere;
参考文献
Beresneva; Abele
Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 9 p. 1420 - 1422
Khim. Geterotsikl. Soedin., 2012 , vol. 48, # 9 p. 1521 - 1524,3
反应条件
1: 5-bromo-1,3-benzothiazol-2-amine With N,N,N',N,-tetramethylethylenediamine; tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 0.5 h;
2: tri-isopropoxy-borane in tetrahydrofuran; pentane
T=-78 - 20°C; 2 h;
参考文献
Shoda, Motoshi; Kuriyama, Hiroshi
Patent: US2004/44258 A1, 2004 ;
Location in patent: Page 97-98 ;
