2-氨基-5-氟苯并噻唑合成路线 （共 14 条）
反应条件
bromine in dichloromethane 3 h; Heating;
参考文献
Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607
反应条件
bromine in dichloromethane; water
参考文献
Tremont, Samuel J.; Koeller, Kevin J.; Neumann, William L.
Patent: US2002/183307 A1, 2002 ;
反应条件
bromine; acetic acid T=0°C; 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 9 p. 3044 - 3049
反应条件
bromine in dichloromethane 3 h; Heating;
参考文献
Schnur, Rodney C.; Fliri, Anton F. J.; Kajiji, Shama; Pollack, Vincent A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 914 - 918
反应条件
1: aq. NaOH / acetone / 1.5 h / Heating 2: 66 percent / Br2 / CH2Cl2 / 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 3 p. 914 - 918
反应条件
1.1: benzoyl chloride / acetone / 1 h / Heating 1.2: 91 percent / aq. NaOH / 1.5 h / Heating 2.1: 64 percent / bromine / CH2Cl2 / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8599 - 8607
反应条件
hydrogenchloride; iron
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 268 - 272
反应条件
1: (i) aq. H2SO4, NaNO2, (ii) /BRN= 3594799/, CuSCN 2: Fe, aq. HCl View Scheme
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 268 - 272
反应条件
potassium hydroxide 5 h; Heating;
参考文献
Hutchinson; Chua; Browne; Trapani; Bradshaw; Westwell; Stevens
Journal of Medicinal Chemistry, 2001 , vol. 44, # 9 p. 1446 - 1455
反应条件
1: 76 percent / aq. potassium hydroxide / 5 h / Heating 2: 90 percent / p-toluenesulfonic acid; triphenylphosphine / 15 h / Heating View Scheme
参考文献
Wang, Kai; Guengerich, F. Peter
Chemical Research in Toxicology, 2012 , vol. 25, # 8 p. 1740 - 1751
