2,2-二甲基-1,2,3,4-四氢喹啉合成路线 （共 9 条）
反应条件
1: H2SO4, HNO3 / 10 h / -10 °C 2: H2 / Pd/C / ethyl acetate / 15 h / Ambient temperature View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
hydrogen; palladium on activated charcoal in ethanol; ethyl acetate
4 h;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 74 percent / CuCl / tetrahydrofuran / 14 h / Heating
2: 99 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 4 h
View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 1.) CH3Li, t-butyllithium, 2.) tetrakis<iodo(tributylphosphine)copper(I)> / 1.) THF, -78 deg C, 1 min, 2.) THF, - 78 deg C, 5 min
2: 89 percent / KOH / methanol / 1 h / Heating
3: 1.) Hg(OAc)2, 2.) NaBH4, NaOH / 1.) methanol, 10 min, 2.) methanol, 1 min
View Scheme
参考文献
Raner, Kevin D.; Ward, A. David
Australian Journal of Chemistry, 1991 , vol. 44, # 12 p. 1749 - 1760
反应条件
1: 1.) CH3Li, t-butyllithium, 2.) tetrakis<iodo(tributylphosphine)copper(I)> / 1.) THF, -78 deg C, 1 min, 2.) THF, - 78 deg C, 5 min
2: 89 percent / KOH / methanol / 1 h / Heating
3: 1.) Hg(OAc)2, 2.) NaBH4, NaOH / 1.) methanol, 10 min, 2.) methanol, 1 min
View Scheme
参考文献
Raner, Kevin D.; Ward, A. David
Australian Journal of Chemistry, 1991 , vol. 44, # 12 p. 1749 - 1760
参考文献
Clemo; Ghatge
Journal of the Chemical Society, 1955 , p. 4347
参考文献
Clemo; Ghatge
Journal of the Chemical Society, 1955 , p. 4347
参考文献
Clemo; Ghatge
Journal of the Chemical Society, 1955 , p. 4347
反应条件
4-(N,N-dimethlyamino)pyridine; N,N-dimethyl-aniline in xylene
6 h; Heating;
参考文献
Tsushima, Kazunori; Osumi, Tadashi; Matsuo, Noritada; Itaya, Nobushige
Agricultural and Biological Chemistry, 1989 , vol. 53, # 9 p. 2529 - 2530
