4-羟基-4-(2-丙烯基)哌啶-1-羧酸叔丁酯合成路线 （共 7 条）
反应条件
1: With ammonium chloride; zinc in tetrahydrofuran T=10°C; Industry scale; 2: With sulfuric acid; water in tetrahydrofuran pH=~ 6; Industry scale; 3: With sodium hydrogencarbonate in tetrahydrofuran; water; tert-butyl alcohol Industry scale;
参考文献
WO2010/58318 A1, ;
Page/Page column 25-26 ;
WO 2010/058318 A1
反应条件
in tetrahydrofuran; diethyl ether T=0 - 23°C; 18 h;
参考文献
Tetrahedron Letters, , vol. 52, # 48 p. 6457 - 6459
反应条件
zinc in tetrahydrofuran
参考文献
US6265434 B1, ;
US 6265434 B1
反应条件
in methanol; diethyl ether
反应条件
1: With sodium periodate in water; tert-butyl alcohol T=50°C; 0.5 h; Industry scale; 2: With sodium disulfite in water; tert-butyl alcohol T=20 - 50°C; 59 h; Industry scale;
参考文献
PFIZER INC.; LONG, Scott Allen; MEYERS, Marvin Jay; PELC, Matthew James; SCHWEITZER, Barbara Ann; THORARENSEN, Atli; WANG, Lijuan Jane
Patent: WO2010/58318 A1, 2010 ;
Location in patent: Page/Page column 26 ;
WO 2010/058318 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 0 - 23 °C
2.1: RuCl2(tricyclohexylphosphine)2(benzylidene) / dichloromethane / 18 h / 0 - 23 °C
3.1: borane-THF / tetrahydrofuran / 18 h / 0 °C
3.2: 1 h / 0 - 23 °C
View Scheme
参考文献
Cernak, Timothy; Dykstra, Kevin; Levorse, Dorothy; Verras, Andreas; Balkovec, James; Nargund, Ravi; DeVita, Robert
Tetrahedron Letters, 2011 , vol. 52, # 48 p. 6457 - 6459
