4,5-二氟-2-硝基苯甲酸合成路线 （共 16 条）
反应条件
1: With thionyl chloride 17 h; Heating / reflux; 2: With triethylamine in methanol 2 h;
参考文献
Huang, Qi; Kaller, Matthew; Nguyen, Thomas; Norman, Mark H.; Rzasa, Robert; Wang, Hui-Ling; Zhong, Wenge
Patent: US2003/229068 A1, 2003 ;
Location in patent: Page 55 ;
US 20030229068 A1
反应条件
in diethyl ether; ethyl acetate T=0°C; 0.166667 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH and CO KG
Patent: WO2007/87717 A1, 2007 ;
Location in patent: Page/Page column 63 ;
WO 2007/087717 A1
反应条件
1.1: thionyl chloride / 1 h / Reflux 1.2: 2 h / 0 °C 2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1 h / 20 °C View Scheme
参考文献
WO2011/112731 A2, ;
WO 2011/112731 A2
反应条件
1.1: thionyl chloride / 1 h / Reflux 1.2: 2 h / 0 °C 2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1 h / 20 °C 3.1: water; sodium dithionite / ethanol / Reflux View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
反应条件
1: 4,5-Difluoro-2-nitro benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 2 h; 2: ethanol in dichloromethane T=0 - 20°C; 5 h;
参考文献
WO2004/14893 A2, ;
Page 97 ;
反应条件
water; potassium hydroxide
T=50 - 90°C; 0.833333 h;
参考文献
Boehringer Ingelheim International GmbH; Busacca, Carl A.; Eriksson, Magnus C.; Xu, Jinghua; Zeng, Xingzhong
Patent: US8519176 B1, 2013 ;
Location in patent: Page/Page column 12; 13 ;
