(2S,4S)-N-Boc-顺式-4-氟-L-脯氨酸合成路线 (共 10 条)
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=0 - 20°C; 2 h; 2: With hydrogenchloride in water pH=5;
参考文献
SUNSHINE LAKE PHARMA CO.,LTD.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; HU, Bailin; FU, Changping; WU, Xiwei; LI, Shifeng; WANG, Chenglin; ZHANG, Zhikeng
Patent: WO2014/82379 A1, 2014 ;
Location in patent: Page/Page column 144; 145 ;
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Journal of the American Chemical Society, , vol. 125, # 31 p. 9262 - 9263
反应条件
1: 48 percent / morpholinosulfur trifluoride / CH2Cl2 / 20 °C 2: H2 / Pd/C / methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 125, # 31 p. 9262 - 9263
反应条件
palladium monocarbide; palladium in methanol
反应条件
1: (diethylamino)sulfur trifluoride / CH2Cl2 / -78 °C 2: aq. LiOH / methanol; tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 15 p. 4167 - 4172
反应条件
1: 95 percent / Et3N / CH2Cl2 / Ambient temperature 2: 81 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 95 percent / Et3N / CH2Cl2 / Ambient temperature 2: 81 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: With sodium hydroxide; water T=40°C; 2 h; 2: With hydrogenchloride in water T=5°C; pH=5; 3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite Product distribution / selectivity; more than 3 stages;
参考文献
WO2006/80401 A1, ;
Page/Page column 38-40 ;
反应条件
1: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 2: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 23 p. 7418 - 7429
反应条件
1: TFA / CH2Cl2 2: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172