N-Boc-顺式-4-氟-L-脯氨酸甲酯合成路线 （共 24 条）
反应条件
diethylamino-sulfur trifluoride in dichloromethane T=-78 - 20°C; 21 h;
参考文献
SUNSHINE LAKE PHARMA CO.,LTD.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; HU, Bailin; FU, Changping; WU, Xiwei; LI, Shifeng; WANG, Chenglin; ZHANG, Zhikeng
Patent: WO2014/82379 A1, 2014 ;
Location in patent: Page/Page column 144; 145 ;
反应条件
cesium fluoride in 1,1-dimethylpropan-1-ol T=25°C; 1.5 h;
参考文献
Kim, Dong Wook; Ahn, Doo-Sik; Oh, Young-Ho; Lee, Sungyul; Kil, Hee Seup; Oh, Seung Jun; Lee, Sang Ju; Kim, Jae Seung; Ryu, Jin Sook; Moon, Dae Hyuk; Chi, Dae Yoon
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 16394 - 16397
反应条件
tetrabutylammonium fluoride hydrofluoride in dichloromethane T=20°C; 2 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
1: methyl (2S,4S)-N-Cbz-4-fluoropyrrolidine-2-carboxylate With hydrogen; palladium on activated charcoal in ethanol T=20°C; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=20°C; 3 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2005/121135 A1, 2005 ;
Location in patent: Page/Page column 68-69 ;
反应条件
cesium fluoride in tert-butyl alcohol T=100°C; 7 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
[Cu(2,9-dimethyl-1,10-phenanthroline)2]*-[HF2]− in acetonitrile T=110°C; 15 h; Schlenk techniqueInert atmosphere; Concentration;
参考文献
Liu, Yanpin; Chen, Chaohuang; Li, Huaifeng; Huang, Kuo-Wei; Tan, Jianwei; Weng, Zhiqiang
Organometallics, 2013 , vol. 32, # 21 p. 6587 - 6592
反应条件
4,4'-diaminostilbene-2,2'-disulfonic acid T=0 - 20°C;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
disulfonyl fluoride; triethylamine in acetonitrile 2.66667 h; cooling with ice;
参考文献
US2011/251403 A1, ;
Page/Page column 12 ;
反应条件
1: Et3N 2: DAST / CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 50 p. 8929 - 8932
反应条件
1: Et3N 2: DAST / CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 50 p. 8929 - 8932
