N-Boc-顺式-4-氟-L-脯氨酸甲酯合成路线 （共 24 条）
反应条件
1: 95 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 2: 85 percent / DAST / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 42 p. 7809 - 7812
反应条件
1: SOCl2 / 6 h / 0 - 20 °C 2: Et3N; DMAP / CH2Cl2 / 0 - 20 °C 3: DAST / CH2Cl2 / 12 h / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 37 p. 6553 - 6556
反应条件
sodium azide; disulfonyl fluoride; tetra-N-butylammonium azide; triethylamine in acetonitrile 1 h; cooling with ice; Product distribution / selectivity;
参考文献
US2011/251403 A1, ;
Page/Page column 11-12 ;
反应条件
methanol; 1-diethylamino-1,1-difluoro-2-chloro-2-fluoro-ethane in chloroform T=10 - 60°C; 10 - 15 h; Product distribution / selectivity;
参考文献
TOSOH F-TECH, INC.
Patent: WO2006/103986 A1, 2006 ;
Location in patent: Page/Page column 10-11; 12-13 ;
反应条件
1: in dichloromethane T=5°C; 12 h; 2: With sodium hydrogencarbonate in dichloromethane; water Product distribution / selectivity;
参考文献
WO2006/80401 A1, ;
Page/Page column 42-44 ;
反应条件
1: in toluene T=75°C; 4 h; 2: With potassium hydroxide in water; toluene Product distribution / selectivity;
参考文献
WO2006/80401 A1, ;
Page/Page column 36-38 ;
反应条件
hydrogenchloride in 1,4-dioxane; chloroform T=20°C; 3 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1659123 A1, 2006 ;
Location in patent: Page/Page column 180 ;
反应条件
1: With sodium hydroxide; water T=40°C; 2 h; 2: With hydrogenchloride in water T=5°C; pH=5; 3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: WO2006/80401 A1, 2006 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: lithium hydroxide hydrate / 1,4-dioxane; water / 3 h / 20 °C 2: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 3: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 23 p. 7418 - 7429
反应条件
1.1: trifluoroacetic acid / CH2Cl2 1.2: 37.7 mg / sodium carbonate / H2O / 1.25 h 2.1: manganese oxide / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Leroy, Jacques; Porhiel, Emmanuel; Bondon, Arnaud
Tetrahedron, 2002 , vol. 58, # 33 p. 6713 - 6722
