N-Boc-顺式-4-氟-L-脯氨酸甲酯合成路线 （共 24 条）
反应条件
1: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature 2: TFA / CH2Cl2 3: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=0 - 20°C; 2 h; 2: With hydrogenchloride in water pH=5;
参考文献
SUNSHINE LAKE PHARMA CO.,LTD.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; HU, Bailin; FU, Changping; WU, Xiwei; LI, Shifeng; WANG, Chenglin; ZHANG, Zhikeng
Patent: WO2014/82379 A1, 2014 ;
Location in patent: Page/Page column 144; 145 ;
反应条件
1: With sodium hydroxide; water T=40°C; 2 h; 2: With hydrogenchloride in water T=5°C; pH=5; 3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite Product distribution / selectivity; more than 3 stages;
参考文献
WO2006/80401 A1, ;
Page/Page column 38-40 ;
反应条件
1: With sodium hydroxide; water
T=40°C; 2 h;
2: With hydrogenchloride in water
T=5°C; pH=5;
3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite
Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: WO2006/80401 A1, 2006 ;
Location in patent: Page/Page column 38-40 ;
