N-Boc-反式-4-氟-L-脯氨酸甲酯合成路线 （共 13 条）
反应条件
4,4'-diaminostilbene-2,2'-disulfonic acid in dichloromethane T=-78 - 20°C;
参考文献
O'Neil, Ian A.; Thompson, Stephen; Kalindjian, S. Barret; Jenkins, Terence C.
Tetrahedron Letters, 2003 , vol. 44, # 42 p. 7809 - 7812
反应条件
4,4'-diaminostilbene-2,2'-disulfonic acid in dichloromethane -78 deg C to r.t.;
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: Et3N 2: DAST / CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 50 p. 8929 - 8932
反应条件
1: Et3N 2: DAST / CH2Cl2 / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 50 p. 8929 - 8932
反应条件
1.1: NaOH; water / tetrahydrofuran / 0 °C 1.2: DEAD; PPh3 / tetrahydrofuran / 0 - 20 °C 1.3: Amberlyst-15(R) / methanol / 20 °C 2.1: 81 percent / DAST / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 42 p. 7809 - 7812
反应条件
1: 76 percent / Et3N / CHCl3 / 0 °C 2: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 3: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
methanol; 1-diethylamino-1,1-difluoro-2-chloro-2-fluoro-ethane in chloroform T=10 - 60°C; 10 - 15 h; Product distribution / selectivity;
参考文献
TOSOH F-TECH, INC.
Patent: WO2006/103986 A1, 2006 ;
Location in patent: Page/Page column 10-11; 12-13 ;
反应条件
1: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 2: TFA / CH2Cl2 View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 2: TFA / CH2Cl2 View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 2: TFA / CH2Cl2 View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
