(2S,4s)-Fmoc-4-氟吡咯烷-2-羧酸合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C; 9 h;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 10 p. 1784 - 1787
反应条件
acetic acid; zinc T=20°C;
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1.1: Cs2CO3 / methanol; H2O 1.2: 86.8 percent / dimethylformamide / 0.5 h 2.1: 94 percent / morpholinosulphur trifluoride / CH2Cl2 / 48 h / 20 °C 3.1: TFA / CH2Cl2 / 1 h / 20 °C 4.1: 5.41 g / N-methylmorpholine / CH2Cl2 / 6 h / 20 °C 5.1: 89.8 percent / acetic acid; zinc / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1: 5.41 g / N-methylmorpholine / CH2Cl2 / 6 h / 20 °C 2: 89.8 percent / acetic acid; zinc / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1.1: Cs2CO3 / methanol; H2O 1.2: 86.8 percent / dimethylformamide / 0.5 h 2.1: 94 percent / morpholinosulphur trifluoride / CH2Cl2 / 48 h / 20 °C 3.1: TFA / CH2Cl2 / 1 h / 20 °C 4.1: 5.41 g / N-methylmorpholine / CH2Cl2 / 6 h / 20 °C 5.1: 89.8 percent / acetic acid; zinc / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1: 95 percent / Et3N / CH2Cl2 / Ambient temperature 2: 81 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature 4: TFA / CH2Cl2 5: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 81 percent / DAST / CH2Cl2 / -78 deg C to r.t. 2: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature 3: TFA / CH2Cl2 4: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: TFA / CH2Cl2 2: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature 2: TFA / CH2Cl2 3: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
triethylamine in methanol Yield given;
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
