Fmoc-反式-4-氟-L-脯氨酸合成路线 （共 11 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C; 9 h;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 10 p. 1784 - 1787
反应条件
acetic acid; zinc T=20°C;
参考文献
Doi, Masamitsu; Nishi, Yoshinori; Kiritoshi, Naruto; Iwata, Tomoya; Nago, Mika; Nakano, Hiroaki; Uchiyama, Susumu; Nakazawa, Takashi; Wakamiya, Tateaki; Kobayashi, Yuji
Tetrahedron, 2002 , vol. 58, # 42 p. 8453 - 8459
反应条件
1.1: 94 percent / diethyl ether 2.1: triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran 3.1: 5.18 g / NaOH / toluene; tetrahydrofuran / 1 h / 20 °C 4.1: Cs2CO3 / methanol; H2O 4.2: 88 percent / dimethylformamide / 0.5 h 5.1: 79.4 percent / morpholinosulphur trifluoride / tetrahydrofuran / 48 h / 20 °C 6.1: TFA / CH2Cl2 / 1 h / 20 °C 7.1: 2.22 g / N-methylmorpholine / CH2Cl2 / 6 h / 20 °C 8.1: 95.5 percent / acetic acid; zinc / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1: 2.22 g / N-methylmorpholine / CH2Cl2 / 6 h / 20 °C 2: 95.5 percent / acetic acid; zinc / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1.1: triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran 2.1: 5.18 g / NaOH / toluene; tetrahydrofuran / 1 h / 20 °C 3.1: Cs2CO3 / methanol; H2O 3.2: 88 percent / dimethylformamide / 0.5 h 4.1: 79.4 percent / morpholinosulphur trifluoride / tetrahydrofuran / 48 h / 20 °C 5.1: TFA / CH2Cl2 / 1 h / 20 °C 6.1: 2.22 g / N-methylmorpholine / CH2Cl2 / 6 h / 20 °C 7.1: 95.5 percent / acetic acid; zinc / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1.1: 94 percent / diethyl ether 2.1: triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran 3.1: 5.18 g / NaOH / toluene; tetrahydrofuran / 1 h / 20 °C 4.1: Cs2CO3 / methanol; H2O 4.2: 88 percent / dimethylformamide / 0.5 h 5.1: 79.4 percent / morpholinosulphur trifluoride / tetrahydrofuran / 48 h / 20 °C 6.1: TFA / CH2Cl2 / 1 h / 20 °C 7.1: 2.22 g / N-methylmorpholine / CH2Cl2 / 6 h / 20 °C 8.1: 95.5 percent / acetic acid; zinc / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8453 - 8459
反应条件
1: 76 percent / Et3N / CHCl3 / 0 °C 2: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 3: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 4: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 5: TFA / CH2Cl2 6: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 2: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 4: TFA / CH2Cl2 5: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: TFA / CH2Cl2 2: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 2: TFA / CH2Cl2 3: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
