2,2-二甲基苯并二氢吡喃-6-羧酸合成路线 （共 11 条）
反应条件
sodium hydroxide; sodium hypochlorite in 1,4-dioxane T=65°C; 96 h;
参考文献
Teng, Min; Duong, Tien T.; Johnson, Alan T.; Klein, Elliott S.; Wang, Liming; Khalifa, Berket; Chandraratna, Roshantha A. S.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2445 - 2451
反应条件
sodium hydroxide; I2 in 1,4-dioxane; tetrachloromethane
参考文献
Allergan Sales, Inc.
Patent: US5877207 A1, 1999 ;
反应条件
potassium permanganate in water T=100°C; 1.5 h;
参考文献
Fatope; Abraham
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1973 - 1977
反应条件
bismuth trifluoromethanesulphonate in toluene T=40°C; 24 h; Inert atmosphereSealed tube;
参考文献
Judd, Katie E.; Caggiano, Lorenzo
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 14 p. 5201 - 5210
反应条件
1: 54 percent / AlCl3 / CH2Cl2 / 0.5 h / Ambient temperature 2: 92 percent / 5.25percent aq. NaOCl, NaOH / dioxane / 96 h / 65 °C View Scheme
参考文献
Jetson, Rachael; Malik, Neha; Luniwal, Amarjit; Chari, Venkatesh; Ratnam, Manohar; Erhardt, Paul
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 104 - 108
反应条件
1: 100 percent / 15percent aq. H2SO4 / benzene / 2 h / 105 °C 2: 54 percent / AlCl3 / CH2Cl2 / 0.5 h / Ambient temperature 3: 92 percent / 5.25percent aq. NaOCl, NaOH / dioxane / 96 h / 65 °C View Scheme
参考文献
Jetson, Rachael; Malik, Neha; Luniwal, Amarjit; Chari, Venkatesh; Ratnam, Manohar; Erhardt, Paul
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 104 - 108
反应条件
1: sodium / anschliessendes Behandeln mit 1-Brom-3-methyl-but-2-en 2: aqueous methanol. hydrochloric acid / Erwaermen des Reaktionsprodukts mit wss. Natronlauge View Scheme
参考文献
Kaczka et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 4125
反应条件
acetic acid; zinc(II) chloride Behandeln des Reaktionsprodukts mit aethanol. Kalilauge;
参考文献
Lauer; Moe
Journal of the American Chemical Society, 1943 , vol. 65, p. 289,292
参考文献
Hinman et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 3789,3795
反应条件
sulfuric acid in ethanol
T=95°C;
参考文献
Jetson, Rachael; Malik, Neha; Luniwal, Amarjit; Chari, Venkatesh; Ratnam, Manohar; Erhardt, Paul
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 104 - 108
