1: hydrogenchloride / water / 1 h / 60 °C 2: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 3: hydrogen bromide; water / 5 h / |Reflux 4: triethylamine / tetrahydrofuran; water View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
potassium hydroxide; chloroformic acid ethyl ester Erhitzen des Reaktionsprodukts mit Phosphorylchlorid und wenig Phosphor(V)-oxid in Xylol auf 130grad-140grad;
1: With triethylamine in dichloromethane
T=20°C; 1.5 h; Ice cooling;
2: With trichlorophosphate in toluene
T=40°C; Reflux;
3: With sodium hydroxide in water
pH=10;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2009/105206 A1, 2009 ;
Location in patent: Page/Page column 88 ;
WO 2009/105206 A1
