water; magnesium in tetrahydrofuran; diethyl ether byproducts: C4H9OH; preparation of Grignard-compound in THF, addn. of soln. to excess B(OC4H9)3 in ether at -70°C, warming to room temp., hydrolysis mit 3n HCl, extractn. with ether, removal of ether, addn. of H2O, removal of C4H9OH;;
1: trans-2-bromostyrene With iodine; magnesium in tetrahydrofuran
T=70°C; Inert atmosphere;
2: carbon dioxide in tetrahydrofuran
Cooling;
3: With hydrogenchloride; water in tetrahydrofuran
参考文献
Cottrell, Ian F.; Cowley, Andrew R.; Croft, Laura J.; Hymns, Lauren; Moloney, Mark G.; Nettleton, Ewan J.; Kirsty Smithies; Thompson, Amber L.
Tetrahedron, 2009 , vol. 65, # 12 p. 2537 - 2550
