2,3-二甲氧基-9H-芴-9-酮合成路线 （共 17 条）
反应条件
cesium fluoride; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene; acetonitrile
T=110°C; 12 h;
参考文献
Waldo, Jesse P.; Zhang, Xiaoxia; Shi, Feng; Larock, Richard C.
Journal of Organic Chemistry, 2008 , vol. 73, # 17 p. 6679 - 6685
反应条件
cesium fluoride; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene; acetonitrile
T=110°C; 12 h;
参考文献
Waldo, Jesse P.; Zhang, Xiaoxia; Shi, Feng; Larock, Richard C.
Journal of Organic Chemistry, 2008 , vol. 73, # 17 p. 6679 - 6685
反应条件
2,2,2-trimethylacetic acid in dimethylammonium 2,4-dichlorophenoxyacetate; toluene
T=120°C; 10 h;
参考文献
Liu, Tao-Ping; Liao, Yuan-Xi; Xing, Chun-Hui; Hu, Qiao-Sheng
Organic Letters, 2011 , vol. 13, # 9 p. 2452 - 2455
反应条件
1: With trifluoroacetic anhydride
T=100°C; 2 h;
2: With hydrogenchloride in water
T=100°C; 2 h;
参考文献
Chinnagolla, Ravi Kiran; Jeganmohan, Masilamani
Organic Letters, 2012 , vol. 14, # 20 p. 5246 - 5249,4
反应条件
1: 1.) BuLi, B(OMe)3, 2.) Na2CO3, H2O / 2.) (PPh3)4Pd / 1.) THF, hexane, -78 deg C, 30 min; 0 deg C, 1.5 h, 2.) DME, EtOH, reflux, 16 h
2: 70 percent / HCl, H2O / 16 h / Heating
3: 94 percent / TFAA / CHCl3 / 0.5 h / Ambient temperature
View Scheme
参考文献
Ciske, Fred L.; Jones Jr., Winton D.
Synthesis, 1998 , # 8 p. 1195 - 1198
反应条件
1: 1.) BuLi, B(OMe)3, 2.) Na2CO3, H2O / 2.) (PPh3)4Pd / 1.) THF, hexane, -78 deg C, 30 min; 0 deg C, 1.5 h, 2.) DME, EtOH, reflux, 16 h
2: 70 percent / HCl, H2O / 16 h / Heating
3: 94 percent / TFAA / CHCl3 / 0.5 h / Ambient temperature
View Scheme
参考文献
Ciske, Fred L.; Jones Jr., Winton D.
Synthesis, 1998 , # 8 p. 1195 - 1198
反应条件
1: C42H62ClO3PPd; potassium carbonate / toluene / 25 h / 80 °C
2: 2,2,2-trimethylacetic acid / dimethylammonium 2,4-dichlorophenoxyacetate; toluene / 10 h / 120 °C
View Scheme
参考文献
Liu, Tao-Ping; Liao, Yuan-Xi; Xing, Chun-Hui; Hu, Qiao-Sheng
Organic Letters, 2011 , vol. 13, # 9 p. 2452 - 2455
反应条件
ethanol; sodium hydride in diphenylether
T=130 - 140°C;
参考文献
Pol,V.A. et al.
Indian Journal of Chemistry, 1969 , vol. 7, p. 557 - 560
反应条件
1.1: {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; silver hexafluoroantimonate; silver(l) oxide / tetrahydrofuran / 16 h / 110 °C / |Inert atmosphere
2.1: trifluoroacetic anhydride / 2 h / 100 °C
2.2: 2 h / 100 °C
View Scheme
参考文献
Chinnagolla, Ravi Kiran; Jeganmohan, Masilamani
Organic Letters, 2012 , vol. 14, # 20 p. 5246 - 5249,4
反应条件
1: polyphosphoric acid
2: NaH, EtOH / diphenyl ether / 130 - 140 °C
View Scheme
参考文献
Pol,V.A. et al.
Indian Journal of Chemistry, 1969 , vol. 7, p. 557 - 560
