1: p-toluenesulfonic acid monohydrate / methanol / 4 h / Heating 2: 1.) NaIO4, aq. NaHCO3, 2.) NaClO2, NaH2PO4 / 1.) CH2Cl2, room temp., 2 h, 2.) CH3CN, H2O, 10 deg C, 2 h 3: diethyl ether 4: 96 percent / H2 / Pd(OH)2/C / methanol View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 77 percent / ZnBr₂ / diethyl ether<br />2: 100 percent / pyridine / CH₂Cl₂ / Ambient temperature<br /> <br /> &nbsp;