2,6-二氯-9-(四氢-2H-吡喃-2-基)-9h-嘌呤合成路线 （共 13 条）
反应条件
1: With toluene-4-sulfonic acid in dichloromethane T=20°C; 4 h; 2: With water; sodium carbonate in dichloromethane
参考文献
IRM LLC; THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2008/94737 A2, 2008 ;
Location in patent: Page/Page column 26-28 ;
WO 2008/094737 A2
反应条件
[bis(acetoxy)iodo]benzene; iodine in 1,2-dichloro-ethane T=70°C; 4.5 h; Irradiation;
参考文献
Guo, Hai-Ming; Xia, Chao; Niu, Hong-Ying; Zhang, Xiao-Ting; Kong, Si-Nan; Wang, Dong-Chao; Qu, Gui-Rong
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 1 p. 53 - 56
反应条件
anhydrous sodium hydrogen carbonate in water; ethyl acetate; pentane
参考文献
Mantell, Simon John; Stephenson, Peter Thomas
Patent: US2002/72597 A1, 2002 ;
反应条件
toluene-4-sulfonic acid in ethyl acetate T=50°C; pH=7; 0.5 h; Heating / reflux;
参考文献
Pfizer Inc
Patent: US6350735 B1, 2002 ;
Location in patent: Page column 5-6 ;
反应条件
1: pyrophosphoryl chloride 2: 86 percent / p-toluenesulphonic acid / ethyl acetate View Scheme
参考文献
Bhakuni, D. S.; Gupta, P. K.; Chowdhury, B. L.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1286 - 1288
反应条件
N-ethyl-N,N-diisopropylamine in isopropyl alcohol 3 h; Inert atmosphereRefluxLarge scale; regioselective reaction;
参考文献
Challenger, Stephen; Dessi, Yann; Fox, Darrell E.; Hesmondhalgh, Lynsey C.; Pascal, Pierre; Pettman, Alan J.; Smith, Julian D.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 575 - 583
参考文献
Mantell, Simon John; Stephenson, Peter Thomas
Patent: US2002/72597 A1, 2002 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / |Inert atmosphere; |Reflux; |Large scale 2: triethylamine; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 21 h / 80 - 82 °C / 7500.75 Torr / |Autoclave; |Inert atmosphere; |Large scale View Scheme
参考文献
Challenger, Stephen; Dessi, Yann; Fox, Darrell E.; Hesmondhalgh, Lynsey C.; Pascal, Pierre; Pettman, Alan J.; Smith, Julian D.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 575 - 583
反应条件
1: 67 percent / Fe(acac)3; N-methylpyrrolidinone / tetrahydrofuran / 8 h / 20 °C 2: 79 percent / Dowex 50X8 (H(1+) form) / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Hocek, Michal; Dvorakova, Hana
Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5773 - 5776
反应条件
hydrogen; palladium on activated charcoal; magnesium oxide
参考文献
Bhakuni, D. S.; Gupta, P. K.; Chowdhury, B. L.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1286 - 1288
