3-氨基-4,4-二甲基-戊酸合成路线 (共 5 条)
反应条件
ammonium acetate in ethanol T=80°C; Rodionov synthesis; 16 h; Large scale reaction;
参考文献
ter Wiel, Matthijs K.J.; Arnold, Mirjam; Peter, Sandra; Troltsch, Ingo; Merget, Stefan; Glaser, Florian; Schwarm, Michael; Bhatti, Harjinder S.; Kuriakose, Biju; Pol, Suryakant S.; Balamurugan, Mohanasundaram; Joshi, Viral V.
Tetrahedron Asymmetry, 2009 , vol. 20, # 4 p. 478 - 482
反应条件
1: Et3N / CH2Cl2 / 24 h / Heating 2: 0.76 g / aq. HCl / 5 h / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 11 p. 1819 - 1821
反应条件
1: thionyl chloride 2: Candida Antarctica lipase / 5 h / 20 °C / Enzymatic reaction View Scheme
参考文献
Grayson, J. Ian; Roos, Juergen; Osswald, Steffen
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1201 - 1206
反应条件
1: thionyl chloride 2: Candida Antarctica lipase / 5 h / 20 °C / Enzymatic reaction View Scheme
参考文献
Grayson, J. Ian; Roos, Juergen; Osswald, Steffen
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1201 - 1206
反应条件
triethylamine in tetrahydrofuran; water T=20°C; 15 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1695961 A1, 2006 ;
Location in patent: Page/Page column 59-60 ;