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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-溴苯腈
合成路线
(共 287 条)
2042-37-7
2-溴苯腈
+
4294-57-9
对甲苯基溴化镁
→
反应条件
613-33-2
4,4'-二甲基联苯
+
114772-53-1
2-氰基-4'-甲基联苯
反应条件
bis-triphenylphosphine-palladium(II) chloride; lithium perchlorate in tetrahydrofuran T=67 - 69°C; 4.5 - 6.5 h; Product distribution / selectivity;
参考文献
CALYX CHEMICALS AND PHARMACEUTICALS LTD.
Patent: WO2008/87656 A2, 2008 ;
Location in patent: Page/Page column 9-11 ;
106-43-4
对氯甲苯
+
2042-37-7
2-溴苯腈
→
反应条件
114772-53-1
2-氰基-4'-甲基联苯
反应条件
NiCl2((PPh3)P)2; triphenylphosphine in tetrahydrofuran T=55°C; 5 h;
参考文献
Miller, Joseph A.; Farrell, Robert P.
Tetrahedron Letters, 1998 , vol. 39, # 36 p. 6441 - 6444
401-78-5
→
反应条件
97067-19-1
+
114772-53-1
2-氰基-4'-甲基联苯
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 10 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
24398-88-7
→
反应条件
114772-53-1
2-氰基-4'-甲基联苯
+
160417-31-2
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 10 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
5798-75-4
→
反应条件
106508-97-8
+
114772-53-1
2-氰基-4'-甲基联苯
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 24 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
→
反应条件
72093-43-7
+
114772-53-1
2-氰基-4'-甲基联苯
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 48 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
2042-37-7
2-溴苯腈
+
100-52-7
→
反应条件
5398-11-8
反应条件
1: 2-cyanophenyl bromide With n-butyllithium in tetrahydrofuran; hexane T=20°C; 2: benzaldehyde in tetrahydrofuran; hexane T=20°C;
参考文献
Nagaki, Aiichiro; Kim, Heejin; Usutani, Hirotsugu; Matsuo, Chika; Yoshida, Jun-Ichi
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 5 p. 1212 - 1217
2042-37-7
2-溴苯腈
+
16419-60-6
→
反应条件
157366-46-6
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium carbonate in ethanol; water; toluene T=80°C; Suzuki-Miyaura cross coupling reaction; Inert atmosphere;
参考文献
Tnay, Ya Lin; Chen, Cheng; Chua, Yi Yuan; Zhang, Line; Chiba, Shunsuke
Organic Letters, 2012 , vol. 14, # 13 p. 3550 - 3553
2042-37-7
2-溴苯腈
→
反应条件
157366-46-6
反应条件
ethylene glycol dimethyl ether; Pd(1,3-bis(diphenylphosphino)-propane)Cl2 in tetrahydrofuran T=65°C; 2 h;
参考文献
Riguet, Eric; Alami, Mouad; Cahiez, Gerard
Journal of Organometallic Chemistry, 2001 , vol. 624, # 1-2 p. 376 - 379
615-37-2
+
2042-37-7
2-溴苯腈
→
反应条件
157366-46-6
反应条件
tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; palladium diacetate in xylene T=130°C; 52 h;
参考文献
Hassan, Jwanro; Hathroubi, Chokri; Gozzi, Christel; Lemaire, Marc
Tetrahedron, 2001 , vol. 57, # 37 p. 7845 - 7855
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