1,2-二(苯基)丙-1-酮合成路线 （共 138 条）
反应条件
1.1: N-chloro-succinimide / tetrachloromethane / 15 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / Inert atmosphere; Cooling
2.2: Inert atmosphere; Cooling
3.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / -45 °C / Inert atmosphere
3.2: -45 - 20 °C / Inert atmosphere
3.3: 1.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Fukuda, Shigehiko; Tsuji, Kazuhito; Musashi, Jun; Nonaka, Ryo; Kimura, Tsutomu; Satoh, Tsuyoshi
Synthesis, 2011 , # 22 art. no. F71511SS, p. 3615 - 3626
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / Inert atmosphere; Cooling
1.2: Inert atmosphere; Cooling
2.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / -45 °C / Inert atmosphere
2.2: -45 - 20 °C / Inert atmosphere
2.3: 1.5 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Fukuda, Shigehiko; Tsuji, Kazuhito; Musashi, Jun; Nonaka, Ryo; Kimura, Tsutomu; Satoh, Tsuyoshi
Synthesis, 2011 , # 22 art. no. F71511SS, p. 3615 - 3626
反应条件
1.1: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C
2.1: dimethylsulfoxide-d6 / 0.5 h
3.1: aq. buffer / 0.25 h / |Inert atmosphere; |Irradiation
4.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C
4.2: 2 h / 3 - 20 °C
View Scheme
参考文献
Kulasekharan, Revathy; Maddipatla, Murthy V. S. N.; Parthasarathy, Anand; Ramamurthy
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 942 - 949
反应条件
1.1: dimethylsulfoxide-d6 / 0.5 h
2.1: aq. buffer / 0.25 h / |Inert atmosphere; |Irradiation
3.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C
3.2: 2 h / 3 - 20 °C
View Scheme
参考文献
Kulasekharan, Revathy; Maddipatla, Murthy V. S. N.; Parthasarathy, Anand; Ramamurthy
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 942 - 949
反应条件
1.1: RuCl2[(S)-(DM-SEGPHOS)][(S)-DAIPEN]; hydrogen; potassium tert-butylate / isopropyl alcohol / 40 h / 25 °C / 5171.62 Torr / |Glovebox
2.1: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C
3.1: dimethylsulfoxide-d6 / 0.5 h
4.1: aq. buffer / 0.25 h / |Inert atmosphere; |Irradiation
5.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C
5.2: 2 h / 3 - 20 °C
View Scheme
参考文献
Kulasekharan, Revathy; Maddipatla, Murthy V. S. N.; Parthasarathy, Anand; Ramamurthy
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 942 - 949
反应条件
1: chloro-trimethyl-silane / tetrahydrofuran / 4 h / 40 °C / |Schlenk technique; |Inert atmosphere
2: tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine; zinc(II) chloride / tetrahydrofuran / 12 h / 28 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Cherney, Alan H.; Reisman, Sarah E.
Tetrahedron, 2014 , vol. 70, # 20 p. 3259 - 3265
反应条件
potassium tert-butylate; FeBr2 in dimethyl sulfoxide
1.5 h;
参考文献
Baumgartner, Maria T.; Jimenez, Liliana B.; Pierini, Adriana B.; Rossi, Roberto A.
Journal of the Chemical Society. Perkin Transactions 2, 2002 , # 6 p. 1092 - 1097
反应条件
1: phosphoryl chloride
2: AlCl3
View Scheme
参考文献
Masuda, Shinji; Nakajima, Tadashi; Suga, Sohei
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 4 p. 1089 - 1094
反应条件
sodium lauryl sulfate in water
Irradiationirrad. of 2,4-diphenylpentan-3-one; var. alkyl sulphate micelles; Product distributionMechanism;
参考文献
Tarasov, Valery F.; Ghatlia, Naresh D.; Buchachenko, Anatolii L.; Tunro, Nicholas J.
Journal of the American Chemical Society, 1992 , vol. 114, # 24 p. 9517 - 9526
反应条件
1: 70 percent / 5-methyl-2-chloro-3-phenyl-2,3-dihydro-1,3,4,2-oxadiazaphosphole, pyridine / Ambient temperature
2: 1.) LDA
View Scheme
参考文献
De Las Heras, Maria A.; Vaquero, Juan J.; Garcia Navio, Jose L.; Alvarez-Builla, Julio
Tetrahedron, 1996 , vol. 52, # 45 p. 14297 - 14310
