2-溴-2-(2-氟苯基)-1-环丙基乙酮合成路线 （共 21 条）
反应条件
bromine in methanol T=25 - 30°C; 6 h; Concentration;
参考文献
WO2013/14295 A1, ;
Page/Page column 19-20 ;
反应条件
1: With iodine; magnesium; isopropyl bromide in tetrahydrofuran T=65°C; 3 h; 2: cyclopropanecarboxylic acid ethyl ester in tetrahydrofuran T=5 - 70°C; 3.16667 h; 3: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile; toluene-4-sulfonic acid in chloroform T=28 - 65°C; 4 h;
参考文献
WO2012/18791 A2, ;
Page/Page column 27-28 ;
反应条件
1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 1.2: 40 - 50 °C 1.3: 0.25 h / 0 - 30 °C 2.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux View Scheme
反应条件
1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 2.2: 40 - 50 °C 2.3: 0.25 h / 0 - 30 °C 3.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux View Scheme
反应条件
1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C 2.1: sodium hydroxide; water / 5 - 95 °C 2.2: pH 2 - 3 3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 3.2: 5 - 65 °C 4.1: dibenzoyl peroxide; N-bromosuccinmide / ethyl acetate / 25 - 60 °C View Scheme
反应条件
1.1: sodium hydroxide; water / 5 - 95 °C 1.2: pH 2 - 3 2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 2.2: 5 - 65 °C 3.1: dibenzoyl peroxide; N-bromosuccinmide / ethyl acetate / 25 - 60 °C View Scheme
反应条件
potassium hydrogencarbonate in acetonitrile T=10 - 15°C;
参考文献
Zhejiang Huahai Pharmaceutical co., Ltd.
Patent: US2012/142927 A1, 2012 ;
Location in patent: Page/Page column 3 ;
反应条件
1: α-cyclopropylcarbonyl-2-fluorobenzyl bromide; 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 1.5 h; 2: acetic anhydride With N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 2 h;
参考文献
WO2011/57592 A1, ;
Page/Page column 10; 11 ;
反应条件
1: α-cyclopropylcarbonyl-2-fluorobenzyl bromide; 5,6,7,7a-tetrahydro-4H-tieno[3,2-c]pyridine-2-on toluene-4-sulfonate With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 1.5 h; 2: acetic anhydride With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=15 - 20°C; 1 h;
参考文献
WO2012/52788 A1, ;
Page/Page column 37-39 ;
反应条件
1: 2-acetoxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine p-toluenesulfonate With sodium hydrogencarbonate in N,N-dimethyl-formamide T=5 - 10°C; 2: α-cyclopropylcarbonyl-2-fluorobenzyl bromide in N,N-dimethyl-formamide T=20°C; 5 h; 3: acetic anhydride in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
WO2009/122440 A1, ;
Page/Page column 33 ;
