1,1,2,2-四氢全氟己基碘合成路线 （共 24 条）
反应条件
tert.-butyl lithium in diethyl ether; hexane T=-78 - 20°C;
参考文献
Nakamura; Linclau; Curran
Journal of the American Chemical Society, 2001 , vol. 123, # 41 p. 10119 - 10120
反应条件
thiourea in ethanol T=80°C;
参考文献
Dieng,S.Y.; Bertaina,B.
Journal of Fluorine Chemistry, 1985 , vol. 28, p. 341
反应条件
1: K2CO3 / tetrahydrofuran / 24 h / 70 °C 2: KOH / ethanol / 80 °C 3: 3 h / 195 °C 4: LiAlH4 / diethyl ether / 12 h / 40 °C 5: ethanol / 1 h / 70 °C View Scheme
参考文献
Mureau, Natacha; Guittard, Frederic; Geribaldi, Serge
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2885 - 2889
反应条件
(10H)-phenothiazine in tert-butyl alcohol T=160°C; 6 h;
参考文献
Asahi Glass Company, Limited
Patent: EP1486482 A1, 2004 ;
Location in patent: Page 5; 6 ;
反应条件
1: malonic acid dimethyl ester With sodium hydride in tetrahydrofuran T=20°C; 0.333333 h; 2: 1-iodo-3,3,4,4,5,5,6,6,6-nonafluorohexane in tetrahydrofuran 18 h; Heating;
参考文献
Trabelsi; Szoenyi; Geribaldi
Journal of Fluorine Chemistry, 2001 , vol. 107, # 1 p. 177 - 181
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran T=20°C; 0.333333 h; 2: 1-iodo-3,3,4,4,5,5,6,6,6-nonafluorohexane in tetrahydrofuran 18 h; Heating;
参考文献
Trabelsi; Szoenyi; Geribaldi
Journal of Fluorine Chemistry, 2001 , vol. 107, # 1 p. 177 - 181
反应条件
potassium hydroxide in ethanol
参考文献
Brace, Neal O.; Marshall, Lawrence W.; Pinson, Carol J.; Wingerden, Gail van
Journal of Organic Chemistry, 1984 , vol. 49, # 13 p. 2361 - 2368
反应条件
1: 85 percent / 95 °C
2: K2CO3 / H2O; dioxane / 95 °C
View Scheme
参考文献
Escoula, B.; Rico, I.; Laval, J. P.; Lattes, A.
Synthetic Communications, 1985 , vol. 15, p. 35 - 38
反应条件
magnesium in diethyl ether
参考文献
De Givenchy, Elisabeth Taffn; Guittard, Frederic; Caillier, Laurent; Munuera, Juan; Geribaldi, Serge
Molecular Crystals and Liquid Crystals, 2005 , vol. 436, p. 237/[1191]-246/[1200]
反应条件
in neat (no solvent)
T=90 - 100°C;
参考文献
Cecutti, Christine; Rico, Isabelle; Lattes, Armand; Novelli, Anne; Rico, Andre; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 485 - 492
