1-碘-1H,1H,2H,2H-全氟辛烷合成路线 （共 102 条）
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran T=20°C; 0.333333 h; 2: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-iodooctane in tetrahydrofuran 18 h; Heating;
参考文献
Trabelsi; Szoenyi; Geribaldi
Journal of Fluorine Chemistry, 2001 , vol. 107, # 1 p. 177 - 181
反应条件
1: diethyl malonate With sodium ethanolate in ethanol T=40°C; 0.25 h; 2: 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-iodooctane in ethanol T=75°C; 28 h;
参考文献
Journal of Fluorine Chemistry, , vol. 107, # 1 p. 177 - 181
→
647-42-73,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛醇+
反应条件
in N,N-dimethyl-formamide T=150°C; 24 h;
参考文献
Journal of Fluorine Chemistry, , vol. 31, p. 151 - 174
→
647-42-73,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛醇+
反应条件
sodium hydroxide in ethanol T=30°C; variation of condition; also with NaOMe; Product distribution;
参考文献
Signe, E.; Blancou, H.; Benefice-Malouet, S.; Itier, J.
Journal of Fluorine Chemistry, 1991 , vol. 54, # 1-3 p. 289
→
647-42-73,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛醇+
反应条件
water; formamide T=150°C; 6 h;
参考文献
Journal of Organic Chemistry, , vol. 58, # 7 p. 1804 - 1811
→
647-42-73,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛醇+
反应条件
water T=140°C; 4.5 h;
参考文献
Journal of Organic Chemistry, , vol. 58, # 7 p. 1804 - 1811
反应条件
in diethyl ether T=25°C;
参考文献
Feiring, Andrew E.; Hovey, Michael C.; Arthur, Samuel D.
Journal of Fluorine Chemistry, 1984 , vol. 24, p. 125 - 132
→
647-42-73,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛醇+
反应条件
water T=130°C; 7 h; Further byproducts given;
参考文献
Journal of Organic Chemistry, , vol. 61, # 19 p. 6504 - 6516
→
647-42-73,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛醇+
反应条件
T=140°C; 7.25 h; Yields of byproduct given;
参考文献
Brace
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 2059 - 2071
→
647-42-73,3,4,4,5,5,6,6,7,7,8,8,8-十三氟-1-辛醇+
反应条件
piperidin-2-one; water; potassium carbonate 1) 140 deg C, 5 h, 2) EtOH, CHCl3, 60 deg C, 4.5 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Brace
Journal of Organic Chemistry, 1996 , vol. 61, # 19 p. 6504 - 6516
