(S)-1,3-二苄基哌嗪合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Reduction; 37 h;
参考文献
Alfaro-Lopez, Josue; Okayama, Toru; Hosohata, Keiko; Davis, Peg; Porreca, Frank; Yamamura, Henry I.; Hruby, Victor J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5359 - 5368
反应条件
1: TFA / CH2Cl2 / 1 h / 20 °C 2: TEA / CH2Cl2 / 2 h / 20 °C 3: 97 percent / LiAlH4 / tetrahydrofuran / 37 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5359 - 5368
反应条件
1: 93 percent / HOBT; dicyclohexylcarbodiimide / CH2Cl2 / 0 - 20 °C 2: TFA / CH2Cl2 / 1 h / 20 °C 3: TEA / CH2Cl2 / 2 h / 20 °C 4: 97 percent / LiAlH4 / tetrahydrofuran / 37 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5359 - 5368
反应条件
1: 93 percent / HOBT; dicyclohexylcarbodiimide / CH2Cl2 / 0 - 20 °C 2: TFA / CH2Cl2 / 1 h / 20 °C 3: TEA / CH2Cl2 / 2 h / 20 °C 4: 97 percent / LiAlH4 / tetrahydrofuran / 37 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5359 - 5368
