反应条件
1: aq. NaOH
2: 70 percent / t-BuOK / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature
3: 1.) n-BuLi, diisopropylamine / 1.) hexane, THF, HMPA, -60 deg C, 2.) hexane, THF, HMPA, -60 deg C, 1 h
View Scheme
参考文献
Aloup, Jean-Claude; Bouchaudon, Jean; Farge, Daniel; James, Claude; Deregnaucourt, Jean; Hardy-Houis, Monique
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 24 - 29
