3-苯基-1-对甲苯丙酮合成路线 （共 47 条）
反应条件
1: magnesium / diethyl ether / 0 - 20 °C
2: manganese(IV) oxide / dichloromethane / 2 h / Reflux
View Scheme
参考文献
Zhou, Jun; Zhang, Guang-Liang; Zou, Jian-Ping; Zhang, Wei
European Journal of Organic Chemistry, 2011 , # 19 p. 3412 - 3415
反应条件
1: 79 percent / potassium tert-butoxide / tetrahydrofuran / 3 h / 50 - 60 °C
2: 68 percent / aq. H2SO4 / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Mangelinckx, Sven; Rooryck, Stijn; Jacobs, Jan; De Kimpe, Norbert
Tetrahedron Letters, 2007 , vol. 48, # 37 p. 6535 - 6538
反应条件
1.1: n-BuLi; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 72 percent / tetrahydrofuran; hexane / 25 h / -78 - 20 °C
2.1: 79 percent / potassium tert-butoxide / tetrahydrofuran / 3 h / 50 - 60 °C
3.1: 68 percent / aq. H2SO4 / tetrahydrofuran / 6 h / Heating
View Scheme
参考文献
Mangelinckx, Sven; Rooryck, Stijn; Jacobs, Jan; De Kimpe, Norbert
Tetrahedron Letters, 2007 , vol. 48, # 37 p. 6535 - 6538
反应条件
1: 89 percent / CrO3, H2SO4
2: 1.) (PPh3)2PdCl2, CuI, 3.) NaHCO3
View Scheme
参考文献
Kundu, Nitya G.; Pal, Manojit; Chowdhury, Chinmay
Journal of Chemical Research, Miniprint, 1995 , # 1 p. 101 - 123
反应条件
palladium; triphenylphosphine in tetrahydrofuran
T=50°C; Negishi Coupling; 6 h; Inert atmosphereGreen chemistry; Catalytic behavior;
参考文献
Wu, Wei-Yi; Lin, Tze-Chiao; Takahashi, Tamotsu; Tsai, Fu-Yu; Mou, Chung-Yuan
ChemCatChem, 2013 , vol. 5, # 4 p. 1011 - 1019
反应条件
1: 1.) (PPh3)2PdCl2, CuI, Et3N / 1.) RT, 0.5 h, 2.) RT, 48 h
2: 83 percent / CrO3, H2SO4 / acetone / 0.75 h / Ambient temperature
View Scheme
参考文献
Kundu, Nitya G.; Pal, Manojit; Chowdhury, Chinmay
Journal of Chemical Research, Miniprint, 1995 , # 1 p. 101 - 123
反应条件
1: caesium carbonate; bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate / dimethyl sulfoxide / 2 h / 100 °C / |Inert atmosphere
2: silica gel; water / dichloromethane / 20 °C / |Inert atmosphere
View Scheme
参考文献
Tang, Ting; Fei, Xiang-Dong; Ge, Zhi-Yuan; Chen, Zhong; Zhu, Yong-Ming; Ji, Shun-Jun
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3170 - 3175
反应条件
1.1: {(2,6-i-Pr2C6H3NC(O)Ph)Eu[N(TMS)2](THF)}2 / neat (no solvent) / 0.05 h / |Inert atmosphere; |Schlenk technique
1.2: 255 / 12 h / 20 °C / |Inert atmosphere; |Schlenk technique
2.1: sulfuric acid; water / 20 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Ding, Hao; Lu, Chengrong; Hu, Xiaolin; Zhao, Bei; Wu, Bing; Yao, Yingming
Synlett, 2013 , vol. 24, # 10 art. no. ST-2013-W0161-L, p. 1269 - 1274
反应条件
lt;(3-dimethylamino)propylgt;dimethylaluminum
1.) toluene, 50 deg C, 0.5 h, 2.) toluene, 80 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Baidossi, Wael; Rosenfeld, Ayelet; Wassermann, Brigit C.; Schutte, Stefan; Schumann, Herbert; Blum, Jochanan
Synthesis, 1996 , # 9 p. 1127 - 1130
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydrogencarbonate
Yield given. Multistep reaction;
参考文献
Kundu, Nitya G.; Pal, Manojit; Chowdhury, Chinmay
Journal of Chemical Research, Miniprint, 1995 , # 1 p. 101 - 123
